AUGUST 2017 IZA DP No. 10944 Ethnic Differences in Duration and Timing of Exposure to Neighbourhood Disadvantage during Childhood This paper examines ethnic differences in childhood neighborhood disadvantage among children living in the Netherlands. In contrast to more conventional approaches for assessing children’s exposure to neighborhood poverty and affluence (e.g., point-in-time and cumula...

The activity of c-Src protein-tyrosine kinase is up-regulated under a number of receptor signaling pathways. However, the activation mechanism of c-Src under physiological conditions has remained unclear. We show here that the Shc adaptor protein is a novel direct activator of c-Src in epidermal growth factor receptor signaling in A431 human epidermoid carcinoma cells. Among the three Shc isofo...

Macrophages comprise the major population of cells infiltrating pancreatic islets during the early stages of infection in DBA/2 mice by the D variant of encephalomyocarditis virus (EMC-D virus). Inactivation of macrophages prior to viral infection almost completely prevents EMC-D virus-induced diabetes. This investigation was initiated to determine whether a tyrosine kinase signalling pathway m...

Background: The molecular mechanism for osteolysis around prostheses remains unclear. Artificial joint loosening is typified by osteolytic resorption. Interleukin-1 affects bone resorption via the MAPK signaling pathway. The aim of this study was to observe the effects of siRNA-silenced expression of interleukin-1 receptor-associated kinase-4 (IRAK-4) gene on the mitogen-activated protein kinas...

Natural killer (NK) cells, a cytotoxic lymphocyte lineage, are able to kill tumor cells in vitro and in mouse models. However, whether these cells display an anti-tumor activity in cancer patients has not been demonstrated. Here we have addressed this issue in patients with several hematological cancers. We found a population of highly activated CD56(dim)CD16(+) NK cells that have recently degr...

Measurements have been performed of scintillation light intensities emitted from various inorganic scintillators irradiated with low-energy beams of highly-charged ions from an electron beam ion source (EBIS) and an electron cyclotron resonance ion source (ECRIS). Beams of xenon ions Xe with various charge states between q=2 and q=18 have been used at energies between 5 keV and 17.5 keV per cha...

Evidence from animal models suggests that natural killer (NK) cells can be important players in the development of type 1 diabetes, although data in humans are still sparse. We studied the frequency and activation state of blood NK cells at different stages of human type 1 diabetes, and whether genetic or phenotypic NK cell peculiarities could be associated with an early onset of diabetes. The ...

Flavonoids have been shown to be effective in protecting against age-related cognitive and motor decline in both in vitro and in vivo models. Recently, a flavonoid-rich extract of Citrus bergamia juice (BJe) has been shown to display anti-oxidant and anti-inflammatory properties against LPS-induced activation of human THP-1 monocytes. In the light of these observations, we wondered whether BJe ...

Delayed cytoprotection (preconditioning) occurs 24 h after sublethal simulated ischaemia and reperfusion (SI/R) in neonatal rat ventricular cardiomyocytes. SI/R was used to investigate the role of activation of mitogen-activated protein kinases (MAPKs), stress-activated protein kinases (SAPKs) and phosphoinositide 3-kinase-dependent protein kinase B (PKB)/Akt in cytoprotection. SI resulted in t...

as the main element of economy, human being has requirements the main one of which is the need for food security and healthy nutrition. unfortunately, in the iranian society there are two groups of people who do not enjoy food security. these groups include people who either do not have the financial means to provide healthy and nutritious food or those who, despite having the financial means, ...