نتایج جستجو برای: p52
تعداد نتایج: 579 فیلتر نتایج به سال:
The oncogene BCR–ABL1 hijacks a B cell signaling protein by inducing the synthesis of a linker protein, according to Feldhahn and colleagues on page 1837. This study helps explain how BCR–ABL1 causes B cell leukemias in humans and identifies a potential new target for drug development. Translocation events that combine unrelated chromosomal sequences are found in up to 65% of human acute leukem...
The NF-kB Regulator Bcl-3 Governs Dendritic Cell Antigen Presentation Functions in Adaptive Immunity
Bcl-3 is an atypical member of the IkB family and modulates gene expression via interaction with p50/NF-kB1 or p52/NF-kB2 homodimers. We report in the present study that Bcl-3 is required in dendritic cells (DCs) to assure effective priming of CD4 and CD8 T cells. Lack of Bcl-3 in bone marrow–derived DCs blunted their ability to expand and promote effector functions of T cells upon Ag/adjuvant ...
BACKGROUND Binding of gonadotropin-releasing hormone (GnRH) to its receptor (GnRHR) on gonadotropes within the anterior pituitary gland is essential to reproduction. In pigs, the GnRHR gene is also located near a genetic marker for ovulation rate, a primary determinant of prolificacy. We hypothesized that pituitary expression of the GnRHR gene is alternatively regulated in genetic strains with ...
This paper studies the duration of new job matches in east and west Germany using data from the German Socio-economic Panel. Non-parametric estimates of the survival probability show that, except for the first years of the east German transition process, job matches are less stable in east Germany. Results from a proportional hazards model that controls for important covariates imply that the t...
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