Leptospirosis is a re-emerging tropical infectious disease [1], is an important zooanthroponotic disease spread-worldwide [2]. The spirochetes of the genus Leptospira is responsible of human and animal leptospirosis characterized as mild febrile illness to severe multiorgan failure, especially pulmonary hemorrhage and renal failure [3]. Pathogenic leptospires are highly motile and invasive spir...

Numerous attempts have been made to control leptospirosis by using chemoprophylaxis, but with limited success. The present study was done investigate the antileptospiral potential of hexane, ethyl acetate and methanol extracts Zingiber zerumbet rhizomes. were assayed for activity broth microdilution method against Leptospira interrogans (serovar Batavie, Canicola, Australis) biflexa serovar Pat...

It is necessary to know the etiological structure of diseases in each region country that affects a particular animal species for successful prevention and diagnosis natural focal diseases, leptospirosis. In this paper, authors presented research materials on distribution pathogenic leptospirosis circulating populations farm animals Yakutia. Currently, 8 unfavorable points have been registered ...

Leptospirosis is a major pig-associated zoonosis worldwide. There are also human occupational disease exposure risks. For better public health and sanitation, the prevalence of this disease was investigated. Four hundred sera were obtained from sows in central Thailand during August 2004 to January 2005 and examined with 20 reference leptospira serovars by a microscopic agglutination test (MAT)...

Whole-cell and detergent-soluble proteins, enriched for outer membrane antigens, of the Leptospira interrogans serovars present in commercially available pentavalent vaccines (hardjo, pomona, icterohaemorrhagiae, grippotyphosa, and canicola) were subjected to sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blotting (immunoblotting). Protein and antigenic profiles of these ...

The use of DNA constructs encoding leptospiral proteins is a promising new approach for vaccination against leptospirosis. In previous work we determined that immunization with hemolysis-associated protein 1 (Hap1) (LipL32) expressed by adenovirus induced significant protection against a virulent Leptospira challenge in gerbils. To avoid the use of the adenovirus vector, we checked for clinical...

ABSTRACT Leptospirosis and toxoplasmosis are zoonoses of occupational character that spread worldwide, mainly in tropical socioeconomically vulnerable areas. Both diseases have vertebrate hosts, which the infectious agent to environment potentially humans can progress fatal cases. The present study reinforces importance One Health for control prophylaxis leptospirosis using sentinel animals are...