BACKGROUND Blood transfusion is associated with side effects caused by residual leukocytes in blood and blood components. Using leukodepleted blood components can decrease some of these adverse effects. Among the various methods to remove leukocytes in blood components, prestorage leukoreduction has been most efficient, but the evidence of clinical side effects awaits further studies. We evalua...

The isolation of Borrelia burgdorferi from blood raises the possibility of bloodborne transmission of Lyme borreliosis through transfusions. To assess this possibility, the ability of B. burgdorferi to survive in human blood processed for transfusion was studied. Human blood was inoculated with B. burgdorferi type strain B-31 (ATCC 35210) at 0.2, 20, or 2000 viable cells/ml, processed by conven...

A method is described for estimating the cell concentration of bacterial suspensions by measurement of the column lengths of packed cells centrifuged into a capillary tube of fine bore. The total error, under the experimental conditions employed, checked by direct count, was >2 per cent for dense suspensions and about 5 per cent for light suspensions. The method is suitable for work requiring r...

Platelets may play a role in the pathogenesis of human cerebral malaria (CM), and they have been shown to induce clumping of Plasmodium falciparum-parasitized red blood cells (PRBCs) in vitro. Both thrombocytopenia and platelet-induced PRBC clumping are associated with severe malaria and, especially, with CM. In the present study, we investigated the occurrence of the clumping phenomenon in pat...

OBJECTIVE This is a repeat cohort study in which we sought to determine whether an association of necrotizing enterocolitis (NEC) <48 hours of a packed red blood cells (PRBC) transfusion was a prior sampling artifact. STUDY DESIGN All very low birth weight neonates with NEC Stage ≥ IIB admitted over an 18-month period were categorized for NEC: (1) <48 hours after a PRBC transfusion; (2) unrel...

BACKGROUND The optimal hemoglobin level and transfusion threshold in patients with septic shock treated with an early, goal oriented approach to resuscitation remains unknown. AIMS To assess the impact of packed red blood cell (PRBC) transfusion on clinically relevant outcomes in patients with septic shock treated with early goal directed therapy (EGDT). SETTINGS AND DESIGN Retrospective co...

colleagues [1] on fresh frozen plasma (FFP) in massive bleedings. We fully agree with their conclusion when they say that we need immediately available universal donor AB plasma. Hemorrhagic shock is the primary cause of avoidable mortality in combatants. Data from the recent US army war experience show clearly that in cases of massive transfusion the transfusion policy strongly impacts mortali...

HYPOTHESIS Old and young trauma patients are capable of hyperdynamic response during standardized shock resuscitation. DESIGN The responses of old and young trauma patients resuscitated using a standardized protocol are compared in an inception cohort study. A standardized resuscitation protocol was used to attain and maintain an oxygen delivery index of 600 mL/min x m2 or greater (DO2I > or ...

Forty patients of Thalassemia Major children were treated with wheat grass tablets (WGT). The mean hemoglobin in the pre WGT was 8.54 +/- 0.33 g% whereas in WGT period was 9.13 +/- 0.14 g% (p < 0.001). The mean blood transfused as packed cells in pre WGT period was 326.82 +/- 74.10 ml/kg/year whereas during WGT period it was 256.39 +/- 45.47 ml/kg/year. The percentage difference in the amount o...

This study was conducted to ascertain the toxicity effect of Indigofera tinctoria on haematology and oxidative stress biomarker liver, kidney, gills, tissue Nile tilapia (Oreochromis niloticus) juveniles. Matured leaves were collected, dried, pulverized. Graded levels leaf powder weighed dissolved in 250 ml water. Fish specimens exposed sub-acute concentrations for 21 days. Significant changes ...