BACKGROUND Bone metastases are highly frequent complications of breast cancers. Current bone metastasis treatments using powerful anti-resorptive agents are only palliative indicating that factors independent of bone resorption control bone metastasis progression. Autotaxin (ATX/NPP2) is a secreted protein with both oncogenic and pro-metastatic properties. Through its lysosphospholipase D (lyso...

Prostate cancer is the most common cancer in men in Western countries, with a high incidence of bone metastasis. The bony metastasis is incurable and contributes significantly to disease-specific morbidity and mortality. The molecular and cellular mechanisms leading to the development of bone metastasis in prostate cancer remain unclear, but are currently under intensive investigation. In this ...

Fibrous dysplasia is a rare bone disease. It accounts for about 2.5% of diseases and 7% tumors. We report the case 9years old girl admitted management painful right supraclavicular swelling evolving in context conservation general status whom paraclinical assessment was favor fibrous clavicle.

AIM The early and precise diagnosis and proper palliative treatment of bone metastasis is important for improving the quality of life of cervical cancer patients. The aim of this study was to clarify the clinical features, treatment modalities and prognosis of bone metastasis in cervical cancer patients in Japan. METHODS The medical records of 75 cervical cancer patients with bone metastasis ...

background : a significant number of patients who receive palliative irradiation for painful bone metastases experience pain flare, defined as a distressing transient increase in pain not immediately controlled by additional analgesics. this pain is postulated to be due to edema at the onset of radiotherapy. this study aims to compare the incidence of bone pain flare among patients who receive ...