A 42-year-old female patient was admitted due to epigastric pain and weight loss. Her past medical history was otherwise negative apart from cigarette smoking. Her physical examination was unremarkable. C-reactive protein and erythrocyte sedimentation rate were raised up to 14.8 mg/ dL and 51 mm/h respectively, platelets were 453,000, while the remaining laboratory tests were normal. Upper gast...

CASE SUMMARY A 14-year-old neutered male Siamese cat was presented with a 3 month history of lethargy, inappetence, dehydration, hindlimb ataxia and intermittent proprioceptive deficits in the hindlimbs. Physical examination revealed low body condition score (1.75/5), pallor and bilateral basilar grade II/VI systolic heart murmur. Neurological examination revealed hindlimb ataxia, severe atroph...

The aim of the current study was to investigate the effect of the PKM2 gene on the proliferation, invasion, migration and apoptosis of Panc‑1 and Sw1990 pancreatic cancer cells via its interaction with the mitogen‑activated protein kinases (MAPKs) signaling pathways. The expression levels of PKM2 protein in pancreatic cancer cells and the corresponding normal tissues was determined with western...

the p53 protein function is essential for the maintenance of the nontumorigenic cell phenotype. pancreatic tumor cells show a very high frequency of p53 mutation. to determine if restoration of wild type p53 function can be used to eliminate the tumorigenic phenotype in these cells, pancreatic tumor cell lines, panc-1 and htb80, differing in p53 status were stably transfected with exogenous wil...

Chidamide is a newly designed histone deacetylase (HDAC) inhibitor that has been applied in clinical trials. This study aimed to test the effect of Chidamide on proliferation and apoptosis in pancreatic cancer cell lines and in vivo tumors, as well as to determine the underlying mechanism. The PaTu8988 pancreatic tumor cell line either in culture or inoculated in nude mice were used to evaluate...

BACKGROUND Metastases to the pancreas are rare, and usually mistaken for primary pancreatic cancers. This study aimed to describe the histology results of solid pancreatic tumours obtained by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) for diagnosis of metastases to the pancreas. METHODS In a retrospective review, patients with pancreatic solid tumours and history of previou...

A case of primary malignant non-Hodgkin's lymphoma of the breast is reported. This is the first well-documented case of breast lymphoma in our institution and also in Iran. The diagnosis of primary breast lymphoma requires the presence of lymphomatous infiltration in close ass, tissue in patients with neither previous lymphoma nor concurrent lymphoma in another site. There is no definite cl...

protein losing enteropathy (ple) as an initial finding of lymphoma, is extremely rare in childhood. we describe clinical and pathological features of an unusual case of gastrointestinal lymphoma presented with ple as a sole manifestation. differential diagnosis in children presenting with ple is critical because early diagnosis and treatment are important for survival in patients with lymphoma.