N-methyl-D-aspartate (NMDA) receptor antibody encephalitis is an immunotherapy-responsive panencephalitis. Patients usually present with characteristic clinical features in a specific order. We describe a patient who developed anti NMDA receptor encephalitis with a positive liquor EBV titer, suggesting formation of antibodies including anti NMDA. After a prolonged ICU stay the patient had a slo...

The parieto-occipital region of the brain is the most frequently and severely affected in subacute sclerosing panencephalitis (SSPE). The basal ganglia, cerebellum and corpus callosum are less commonly involved. We describe a patient with SSPE confirmed by neuropathology based on brain magnetic resonance imaging showing extensive basal ganglia involvement and no significant involvement of other...

Subacute sclerosing panencephalitis (SSPE) is a progressive neurological disorder of childhood and early adolescence caused by persistent defective measles virus. Clinical manifestations appear many years after the acute measles infection. The incidence of SSPE has substantially declined after the introduction of an effective vaccine. We report a case of a child with SSPE that began with atonia...

Subacute sclerosing panencephalitis (SSPE) is a progressive central nervous system disorder affecting both grey and white matter; it affects children and young adults and, with only occasional exceptions, is fatal. Present interest in the illness stems from the observation that the disease is due to a slow virus infection produced by measles or a measles-like virus (Horta-Barbo-a, Fuccillo, and...

OBJECTIVE To determine the clinical and demographic characteristics of children diagnosed with Subacute sclerosing panencephalitis (SSPE). STUDY DESIGN Case series. PLACE AND DURATION OF STUDY The Aga Khan University Hospital, Karachi, from January 2000 to June 2012. METHODOLOGY A retrospective analysis was done, regarding medical charts of 43 children under the age of 16 years with a dis...

Panencephalitis We read with great interest the recent contribution by Aydin et al in the February issue of the American Journal of Neuroradiology. They demonstrated gray matter volume reduction in the frontotemporal cortex of patients with subacute sclerosing panencephalitis (SSPE) without any apparent lesions on MR imaging. The authors achieved excellent results from their imaging assessment ...

Subacute sclerosing panencephalitis (SSPE) is a ravaging disease of the central nervous system caused by persistent mutant measles virus. The diagnosis SSPE based on characteristic clinical and EEG findings demonstration elevated antibody titres against in cerebrospinal fluid. may have atypical features at onset. Herein, we report an case adolescent with bilateral retinitis as initial presentin...