I. Vezér, T., Schulz, H., Nagymajtényi, L.: memory effects following subchronic organic and inorganic lead administration in rats. J. Physiol. (London) 526: 162P-163P (2000) Impact factor: 4,455 II. Vezér, T., Papp, A., Nagymajtényi, L.: Behavioral and neurotoxicological alterations induced by subchronic inorganic lead and mercury treatment in rats. Neurobiology 9: 273 (2001) III. Vezér, T., Pa...

BACKGROUND First trimester screening (FTS) for Down syndrome combines measurement of nuchal translucency, free beta-human chorionic gonadotrophin and pregnancy-associated plasma protein-A (PAPP-A). The aim of this study was to undertake a detailed analysis of FTS results in singleton pregnancies conceived using assisted reproductive technologies (ART) and non-ART pregnancies. METHODS A record...

OBJECTIVE To examine whether in pregnancies with fetal trisomy 21 the level of maternal serum free beta-human chorionic gonadotropin (beta-hCG) and pregnancy-associated plasma protein-A (PAPP-A) at 11 + 0 to 13 + 6 weeks' gestation is independent of the presence or absence of tricuspid regurgitation and to estimate the performance of a screening test that combines tricuspid regurgitation with f...

background: determination of oocyte fertilization and embryo quality are one of the most important purposes in art cycles. follicular fluid provides an important microenvironment for development of oocytes and some biochemical characteristics of the follicular fluid, such as pregnancy-associated plasma protein-a (papp-a), may play an important role in prediction of success rate of art. objectiv...

OBJECTIVE To validate previously computed correction factors for free β-human chorionic gonadotrophin (fβ-hCG) and pregnancy-associated plasma protein-A (PAPP-A) in in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) pregnancies with hormone treatment and to determine the effect on false-positive rate (FPR). METHODS Retrospective study on 249 IVF and 250 ICSI cases and 20...

OBJECTIVE Pregnancy associated plasma protein-A2 (PAPP-A2) is a protease that cleaves insulin-like growth factor binding protein-5 (IGFBP-5), the most abundant IGFBP in bone. Deletion of Pappa2 reduces postnatal growth and bone length in mice. The aim of this study was to determine whether locally produced PAPP-A2 is required for normal bone growth. DESIGN We deleted Pappa2 primarily in osteo...

BACKGROUND PAPP-A is a marker used as part of the most effective method of screening for chromosomal anomalies in the first trimester. ADAM12 is a recently discovered pregnancy associated member of the ADAM (a multidomain glycoprotein metalloprotease) family. Recently, ADAM12 has been shown as a potential marker for early screening for chromosomal anomalies. Both PAPP-A and ADAM12 have been ide...