This paper describes the experience gained while parallelizing the global medium range weather forecasting application called TSO on a PARAM machine based on a distributed memory parallel architecture. The TSO code employs the spectral method for horizontal directions and finite differencing in the vertical direction and time marching. The parallel implementation takes care of the easy portabil...

The ability to assemble discrete nanowires (NWs) with nanoscale precision on a substrate is the key to their integration into circuits and other functional systems. We demonstrate a bottom-up approach for massively parallel deterministic assembly of discrete NWs based on surface-guided horizontal growth from nanopatterned catalyst. The guided growth and the catalyst nanopattern define the direc...

Amyloid beta (Aβ) peptides produced by APP cleavage are central to the pathology of Alzheimer's disease. Despite widespread interest in this issue, the relationship between the auto-assembly and toxicity of these peptides remains controversial. One intriguing feature stems from their capacity to form anti-parallel ß-sheet oligomeric intermediates that can be converted into a parallel topology t...

Next generation sequencing (NGS) is superseding Sanger technology for analysing intra-host viral populations, in terms of genome length and resolution. We introduce two new empirical validation data sets and test the available viral population assembly software. Two intra-host viral population 'quasispecies' samples (type-1 human immunodeficiency and hepatitis C virus) were Sanger-sequenced, an...

Having non-singular assembly modes changing trajectories for the 3-RPS parallel robot is a well-known feature. The only known solution for defining such trajectory is to encircle a cusp point in the joint space. In this paper, the aspects and the characteristic surfaces are computed for each operation mode to define the uniqueness of the domains. Thus, we can easily see in the workspace that at...

In this paper, a novel unsymmetrical five–four bar Planar Parallel Manipulator (PPM) with three Degree-of-Freedoms (DOFs) is proposed, the new manipulator is composed of a double-layer five-bar part with a four-bar part located in between. Targeting for the application of Chinese dish cooking machine, the detailed kinematics analysis for the new PPM is developed. Different from traditional thre...

diamondoids are cage-like saturated hydrocarbons consisting of fused cyclohexane rings. thediamondoids family of compounds is one of the best candidates for molecular building blocks (mbbs)in nanotechnology to construct organic nanostructures compared to other mbbs known so far. thechallenge is to find a route for self-assembly of these cage hydrocarbons and their applications in thebottom-up s...

objectives: nowadays, snap-fits are used in the automotive industry as a proper alternative for mechanical joints, cabling joints, and car interior lining joints. due to the special form of these joints, which are assembled manually, the contact area between snap-fits and the worker's fingertips can be too small. this can cause skin pain on the worker's fingertips. therefore, an ergonomic study...

with the growth in customers’ demand diversification, mixed-model u-lines (mmul) have acquired increasing importance in the area of assembly systems. there are generally two different approaches in the literature for balancing such systems. some researchers believe that since the types of models can be very diverse, a balancing approach without simultaneously sequencing of models will not yield...

The ribosome is a complex macromolecular machine and serves as an ideal system for understanding biological macromolecular assembly. Direct observation of ribosome assembly in vivo is difficult, as few intermediates have been isolated and thoroughly characterized. Herein, we deploy a genetic system to starve cells of an essential ribosomal protein, which results in the accumulation of assembly ...