Accumulation of aluminum in bone is a frequent finding in patients requiring chronic dialysis and is associated with considerable morbidity and/or mortality. Until now, evidence seemed to point to relatively low circulating levels of parathyroid hormone as a contributing factor, but because levels of parathyroid hormone and calcitriol are interrelated, calcitriol might be also involved. In this...

Parathyroid hormone decreased the incorporation of [3H]proline into collagenase-digestible protein in cultured 21-day fetal rat calvaria but had little effect on the labeling of noncollagen protein. After 24 hr of culture, there was a 50% reduction in collaghen synthesis and a 40% decrease in the level of functional procollagen mRNA as measured in a reticulocyte lystate translation assay. The e...

the observed differences between the two methods. Our study is even more intriguing if we consider that, very recently, a new molecular form of PTH, with structural integrity of the PTH(1– 4) region and a modified PTH(15–20) region, has been identified by HPLC in primary and secondary hyperparathyroidism (21). In fact, this newly discovered form of PTH appears to be immu-noreactive and detectab...

1 Speziale MV, Mannino FL, Hastings RH, et al. Parathyroid hormone-related protein in tracheal aspirates of newborn infants. Pediatr Res 1998; 43:660–665 2 Hastings RH, Auger WR, Kerr KM, et al. Parathyroid hormone-related protein and lung injury after pulmonary thromboendarterectomy. Regul Pept 2001; 102:1–7 3 Stern JB, Bernard O, Paugam C, et al. Parathyroid hormonerelated protein in epitheli...

Parathyroid carcinoma is the rarest endocrine cancer with aggressive behaviour. It may be presented as a feature of severe hypercalcemia, musculoskeletal involvement and neck mass. There should high clinical suspicion if there marked very parathyroid hormone levels, palpable mass, recurrent laryngeal nerve palsy due to invasion bone renal symptoms. Thyroid pathology has been seen in 15-70% pati...

background: vitamin d deficiency is a pandemic problem mostly diagnosed in elderly. few studies are available exclusively done on the topic among young adults. specific professions such as medical students may have higher risk for developing hypovitaminosis d. we aimed to assess the vitamin d status in medical students of iran university of medical sciences; and to define a cut‑off point for 25...

In this article we demonstrate receptors for parathyroid hormone in circulating mononuclear leukocytes using the radioiodinated analogue (8,18 norleucine, 34 tyrosine) bPTH 1-34 (bovine parathyroid hormone 1-34). Specific binding, which is reversible and saturable, equilibrates within 5 min at 0-4 degrees C with a calculated KD of 8.9 X 10(-11) M. This binding has a pH maximum of 7.0, is magnes...