OBJECTIVE To assess the diagnostic accuracy of fine-needle aspiration (FNA) of the parotid and submandibular glands. STUDY DESIGN Case series with chart review. SETTING Tertiary referral academic center. SUBJECTS AND METHODS Retrospective analysis was performed for all parotid and submandibular gland FNAs from a single center from 2001 to 2014. There were 1283 FNAs performed for 1076 pati...

In this study, we sought to understand the selective pressures shaping the Ig-producing cell repertoire in the parotid glands of primary Sjögren's syndrome (pSS) patients before and after rituximab treatment (RTX). In particular, we evaluated the role of potential N-glycosylation motifs acquired by somatic hypermutation (ac-Nglycs) within Ig H chain V region (IGHV) genes as alternative selectiv...

Salivary gland cancers are uncommon malignancies of the head and neck region. Their site of origin can be major (parotid, submandibular and sublingual) or minor salivary gland (palate, nasal cavity, paranasal sinuses, trachea and lacrimal gland). Of all the salivary gland neoplasms, 85% are benign and 15% are malignant. Salivary gland malignancies comprise 3-6% of all head and neck cancers (Pin...

UNLABELLED Pleomorphic adenoma is a benign epithelial tumor of adenoid structure preferentially arising from the parotid gland. It was shown that complete tumor excision is a curative measure and recurrence is likely in incompletely excised tumors. The aim of this study was to analyse the outcome of patients with pleomorphic adenoma from salivary glands in order to evaluate the surgical strateg...

A 2 1/2-year-old female presented to the Department of Paediatrics with a fever (38.2 degrees C) and bilateral swelling of the parotid salivary glands. A month later, she presented with similar signs and symptoms. Three months later the patient had a third attack and was referred to the Paediatric Dental Department. A clinical examination and sialography showed a normal Stensen's duct. The pare...

We determined mRNA levels of bone morphogenetic protein 7 (BMP7), a growth and differentiation factor belonging to the transforming growth factor-beta superfamily, in the salivary glands of mice with streptozotocin (200 mg/kg, i.p.)-induced diabetes. We also examined the effects of BMP7 on secretion of saliva and degenerative change in salivary glands in diabetic mice. In normal mice, BMP7 mRNA...

Hyposecretion of saliva and consequent dry mouth lead to severe caries and periodontal disease. Therapeutic radiation for head and neck cancer and sialadenitis result in atrophy and fibrosis of salivary glands, but the mechanism is not clear. As a model for dysfunction of salivary glands, we examined the change of gene expression patterns in primary cultured parotid acinar cells. The expression...