The objective of the present study was to propose an orthosis of light material that would be functional for the animal and that would maintain only the ankle joint immobilized. Male Wistar rats (3 to 4 months old, 250-300 g) were divided into 2 groups (N = 6): control and immobilized for 7 days. Rats were anesthetized with sodium pentobarbital (40 mg/kg weight) and the left hindlimb was immobi...

The leukocyte common antigen, CD45, is a critical immune regulator whose activity is modulated by cytoskeletal interactions. Components of the spectrin-ankyrin cytoskeleton have been implicated in the trafficking and signaling of CD45. We have examined the lateral mobility of CD45 in resting and activated T lymphocytes using single-particle tracking and found that the receptor has decreased mob...

RESULTS: The majority of flaps were for lower extremity trauma wounds (74), followed by upper extremity trauma wounds (8), scalp tumor defects (4), and one torso wound. There were 7 flap losses, but of these, 4 were due to noncompliance with postoperative immobilization/elevation orders; excluding these 4 failures for which the NPD was clearly not a factor, the flap success rate was 96.4%. Skin...

RESULTS: The majority of flaps were for lower extremity trauma wounds (74), followed by upper extremity trauma wounds (8), scalp tumor defects (4), and one torso wound. There were 7 flap losses, but of these, 4 were due to noncompliance with postoperative immobilization/elevation orders; excluding these 4 failures for which the NPD was clearly not a factor, the flap success rate was 96.4%. Skin...

The maintenance of skeletal muscle mass contributes substantially to health and to issues associated with the quality of life. It has been well recognized that skeletal muscle mass is regulated by mechanically induced changes in protein synthesis, and that signaling by mTOR is necessary for an increase in protein synthesis and the hypertrophy that occurs in response to increased mechanical load...

The present study examined the effects of inducible nitric oxide synthase (iNOS) deficiency on skeletal muscle atrophy in single leg-immobilized iNOS knockout (KO) and wild-type (WT) mice. The left leg was immobilized for 1 wk, and the right leg was used as the control. Muscle weight and contraction-stimulated glucose uptake were reduced by immobilization in WT mice, which was accompanied with ...

OBJECTIVE To evaluate the effects of spinal immobilization on healthy participants. METHODS A systematic review of randomized, controlled trials of spinal immobilization on healthy participants. RESULTS Seventeen randomized, controlled trials compared different types of immobilization devices, including collars, backboards, splints, and body strapping. For immobilization efficacy, collars, ...