Kinetic analyses of the mechanisms of patulinand gossypolinduced cellular toxicity in an immortalized rat hepatocyte cell line were examined using a battery of vital fluorescence bioassays. Intracellular glutathione (GSH) content and intracellular Ca ([Ca]i) were monitored simultaneously using fluorescent probes requiring uv excitation (351-363 nm); reactive oxygen species (ROS) production, mit...

Mycotoxins are fungal metabolites that are present in a large part of the world food supply and bear potential threat to food safety. The European Union has been working for several years now on the harmonization of some mycotoxin standards for foods based on toxicological evaluation by its Scientific Committee on Food (SCF). These standards will follow the ALARA (as low as reasonably achievabl...

Lung cancer is the most lethal form of cancer in the world. Its development often involves an overactivation of the nuclear factor kappa B (NF-κB) pathway, leading to increased cell proliferation, survival, mobility, and a decrease in apoptosis. Therefore, NF-κB inhibitors are actively sought after for both cancer chemoprevention and therapy, and fungi represent an interesting unexplored reserv...

Synthetic fungicides are commonly employed for the control of postharvest diseases of fruits. However, due to health concerns about the use of these chemicals, alternative control methods including biocontrol based on antagonistic yeasts are gaining in popularity. In this study, we investigated the effects of two biocontrol yeasts, Rhodotorula mucilaginosa strain 3617 and Rhodotorula kratochvil...