BACKGROUND Pancreas organogenesis is the result of well-orchestrated and balanced activities of transcription factors. The homeobox transcription factor PDX-1 plays a crucial role in the development and function of the pancreas, both in the maintenance of progenitor cells and in determination and maintenance of differentiated endocrine cells. However, the activity of homeobox transcription fact...

Vertebrate hox genes, like their Drosophila counterparts the HOM-C genes, play essential roles during embryogenesis. For instance, their expression in overlapping domains along the anteroposterior (AP) axis provides a ‘hox code’ that specifies AP positional identity, and changes in hox gene expression lead to homeotic transformations in the AP axis, wherein anterior structures acquire the chara...

Telephone Switches are characteristically long-lived, evolving systems. We describe how a legacy two-tier system for telephone switch management was reengineered as a three-tier web-based application using CORBA and Java. In this solution the design-time advantages of portability and abstraction brought by an IDL information model are combined with the universality and ease of use of a Java GUI...