Abstract Cancer is one of the main causes death worldwide, being pancreatic cancer second deadliest in Western countries. Surgery, chemotherapy and radiotherapy form basis cancer’s current treatment. However, these techniques have several disadvantages, such as surgery complications, systemic side effects recurrence. Drug delivery systems can reduce effects, increasing effectivity treatment by ...

background: three-dimensional (3d) biomimetic nanofiber scaffolds have widespread applications in biomedical tissue engineering. they provide a suitable environment for cellular adhesion, survival, proliferation and differentiation, guide new tissue formation and development, and are one of the outstanding goals of tissue engineering. electrospinning has recently emerged as a leading technique ...

Metal halide perovskite quantum dots (PQDs) are widely used in the display field due to their excellent photoelectric properties, such as ultra-narrow half-peak widths and ultra-pure luminescence color purity. Inkjet printing, laser direct writing electrospinning all common methods for PQDs printing prepare micropattern displays. In order produce large-scale high-resolution micropatterns, elect...

Antimicrobial properties of silver have been known for a long time, but there is also cytotoxicity high concentrations silver. Therefore, it important to select the concentration and shape depending on goals. The ideal wound dressing should ensure that remains optimally moist, protected from infections, has no toxic compounds, stimulates regeneration. In present work, we obtained series polycap...

Stem cells hold great promise in enhancing nerve regeneration. In particular, human mesenchymal stem cells (MSC) represent a clinically viable cell source due in part to their abundance and accessibility. Unfortunately, current methods to direct the fate of stem cells remains largely limited to biochemical-based approaches on two-dimensional substrates with restricted efficacies. Here we have e...

The electrospinning technique is a versatile method for the production of fibrous scaffolds able to resemble the morphology of the native extra cellular matrix. In the present paper, electrospinning is used to fabricate novel SiO2 particles (type MCM-41) containing poly(epsilon-caprolactone) (PCL) fibers. The main aims of the present work are both the optimization of the particle synthesis and ...

Adult articular cartilage has a limited capacity for growth and regeneration and, with injury, new cellular or biomaterial-based therapeutic platforms are required to promote repair. Tissue engineering aims to produce cartilage-like tissues that recreate the complex mechanical and biological properties found in vivo. In this study, a unique composite scaffold was developed by infiltrating a thr...

purpose: to develop a nanofibrous polycaprolacton (pcl) substrate for limbal stem cell (lsc) expansion that can serve as a potential alternative substrate to replace human amniotic membrane. methods: the human limbal stem cells (lscs) were used to evaluate the biocompatibility of substrates (nanofibrous scaffold, and human amniotic membrane) regarding cellular phenotypic profile, viability, pro...