نتایج جستجو برای: pea

تعداد نتایج: 10287  

2017
Chien-Chao Chiu Yu-Chih Wang Wen-Ching Huang Yi-Hsun Chen Shao-Wen Hung Yen-Te Huang Hsiao-Li Chuang Yi-Chih Chang

Pseudomonas aeruginosa exotoxin A (PEA) causes severe hepatotoxicity in experimental animals and is useful in investigations of immune-mediated liver injury. However, strain differences in the sensitivity to PEA-induced hepatotoxicity in rats remains be elucidated. In this study, we determined the severity of PEA-induced hepatotoxicity in six genetically different rat strains. Male LE (Long Eva...

Journal: :Infection and immunity 2002
Miroslav S Sarac Angus Cameron Iris Lindberg

The Pseudomonas aeruginosa exotoxin A (PEA) protein requires furin-mediated cleavage for manifestation of toxicity. We show here that the small stable furin inhibitor hexa-D-arginine amide effectively blocks PEA-induced cell lysis and is itself noncytotoxic. Administration of hexa-D-arginine to PEA-treated mice significantly improves their survival rate and also decreases circulating levels of ...

Journal: :Plant physiology 1985
J Andrews J B Ohlrogge K Keegstra

The second enzyme of phosphatidic acid synthesis from glycerol-3-phosphate, 1-acylglycerophospate acyltransferase, was localized to the inner envelope membrane of pea chloroplasts. The activity of this enzyme was measured by both a coupled enzyme assay and a direct enzyme assay. Using the coupled enzyme assay, phosphatidic acid phosphatase was also localized to the inner envelope membrane, alth...

2008
Barbara Costa Francesca Comelli Isabella Bettoni Mariapia Colleoni Gabriella Giagnoni

Palmitoylethanolamide (PEA) is an endogenous lipid that is thought to be involved in endogenous protective mechanisms activated as a result of stimulation of inflammatory response. In spite of the well demonstrated anti-inflammatory properties of PEA, its involvement in controlling pain pathways still remains poorly characterized. On this basis, we tested the efficacy of PEA in vivo against a p...

2013
J. M. Keppel Hesselink Tineke de Boer Renger F. Witkamp

Palmitoylethanolamide (PEA) is a food component known since 1957. PEA is synthesized and metabolized in animal cells via a number of enzymes and exerts a multitude of physiological functions related to metabolic homeostasis. Research on PEA has been conducted for more than 50 years, and over 350 papers are referenced in PubMed describing the physiological properties of this endogenous modulator...

2015
Al Imran Malik Tadhamin Iskander Ailewe William Erskine

Waterlogging reduces the yield of food crops. Tolerance to waterlogging could vary between and within species. This study aimed to quantify tolerance to soil waterlogging in two divergent genotypes of pea (Pisum sativum), two of lentil (Lens culinaris) and a grasspea (Lathyrus sativus) control at germination and during vegetative growth. Following germination, seeds were grown for 14 days in so...

2013
L. Di Cesare Mannelli G. D'Agostino A. Pacini R. Russo M. Zanardelli C. Ghelardini A. Calignano

Neuropathic syndromes which are evoked by lesions to the peripheral or central nervous system are extremely difficult to treat, and available drugs rarely joint an antihyperalgesic with a neurorestorative effect. N-Palmitoylethanolamine (PEA) exerts antinociceptive effects in several animal models and inhibits peripheral inflammation in rodents. Aimed to evaluate the antineuropathic properties ...

Journal: :Tropical medicine & international health : TM & IH 2005
Haileyesus Getahun Fernand Lambein Michel Vanhoorne Patrick Van der Stuyft

OBJECTIVE To study an array of household individual and dietary risk factors for neurolathyrism. METHOD Case-control study using recent cases in a district highly affected by the recent neurolathyrism epidemic in Ethiopia: 108 households with cases and 104 households with no cases; 170 neurolathyrism cases, 370 intra-family controls and 170 community controls frequency matched for age and sex...

2011
Amandine Bordat Vincent Savois Marie Nicolas Jérome Salse Aurélie Chauveau Michael Bourgeois Jean Potier Hervé Houtin Céline Rond Florent Murat Pascal Marget Grégoire Aubert Judith Burstin

To identify genes involved in phenotypic traits, translational genomics from highly characterized model plants to poorly characterized crop plants provides a valuable source of markers to saturate a zone of interest as well as functionally characterized candidate genes. In this paper, an integrated view of the pea genetic map was developed. A series of gene markers were mapped and their best re...

Journal: :Neuropharmacology 2005
Nissar A Darmani Angelo A Izzo Brian Degenhardt Marta Valenti Giuseppe Scaglione Raffaele Capasso Italo Sorrentini Vincenzo Di Marzo

The endogenous cannabimimetic compound, and anandamide analogue, N-palmitoyl-ethanolamine (PEA), was shown to exert potent anti-inflammatory and analgesic effects in experimental models of visceral, neuropathic and inflammatory pain by acting via several possible mechanisms. However, only scant data have been reported on the regulation of PEA levels during pathological conditions in animals or,...

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