introduction:  acute lymphoblastic leukemia (all) is the most common malignancy in children and the main form of childhood leukemia (75%). all different treatment options have a great impact on children weight and appetite. the improving prognosis for children with cancer refocuses attention to long-term outcomes with an emphasis on quality of life. more survival rate allows researchers to eval...

background evidence indicates rfc1 g80a polymorphism as a risk factor for a number of cancers. increasing studies have been conducted on the association of rfc1 g80a polymorphism with acute lymphoblastic leukemia (all) risk. however, the results were  controversial. the aim of the present study was to derive a more precise estimation of the relationship.  materials and method pubmed, embase, we...

Introduction: As more data is collected, hematologists will be able to gain insight into the impact of coronavirus disease 2019 (COVID-19) on pediatric patients with hematological malignancies. Material and methods: We analysed 21 cases COVID-19 in onco-hematological diseases treated Western Ukrainian Pediatric Medical Center from March 2020 through May 2021. The majority (71.4%) were diagnosed...

Bone marrow samples from normal adults and children with nonhematologic malignancies not involving the marrow, acute lymphoblastic leukemia (ALL) in continued remission, and immune cytopenias were studied by twocolor immunofluorescence (IF) and flow cytometry to characterize common acute lymphoblastic leukemia antigen (CALLA)-positive marrow lymphoid cells. Marrow was separated by Ficoll/Hypaqu...

Evidence supporting the role of hematopoietic stem cell transplantation (SCT) in the therapy of acute lymphoblastic leukemia (ALL) in children is presented and critically evaluated in this systematic evidence-based review. Specific criteria were used for searching the published literature and for grading the quality and strength of the evidence and the strength of the treatment recommendations....

Acute lymphoblastic leukemia (ALL) constitute a family of genetically heterogeneous lymphoid neoplasms derived from B- and T-lymphoid progenitors. ALL affects both children and adults. Diagnosis is based on morphologic, immunophenotypic, and genetic features that allow differentiation from normal progenitors and other hematopoietic and nonhematopoietic neoplasms. The aim of this study was to in...

MLL/GAS7, resulting from t(11;17)(q23;p13), has been reported in one case of treatment-related acute myeloid leukemia (AML). We present a de novo case of t(11;17)-positive pediatric acute lymphoblastic leukemia. Fluorescent in situ hybridization and reverse transcriptase polymerase chain reaction analyses revealed an MLL/GAS7 chimera identical to the one previously described in AML. The molecul...