Potentiometric titrations of pepsinogen as functions of ionic strength and temperature were studied. It was found that the ionic strength has a minor effect on the titration behavior of the protein. The maximum values of the buffering capacity in the pH range of 6.0 to 9.0 were found at pH values corresponding to those at which a conformational change of the protein occurs as determined by opti...

A study of the kinetics of the transformation of swine pepsinogen into pepsin under a variety of conditions has been made. The results show that the transformation as a whole is essentially autocatalytic in nature under all conditions. Evidence is presented to show the existence of a compound intermediate between pepsinogen and pepsin. This compound was found to be a reversibly dissociable comp...

Evidence relating to the structure and properties of swine pepsinogen and pepsin has been reviewed and used to suggest a tentative two dimensional picture of the skeleton of these two proteins. When pepsinogen, a folded single peptide chain, is converted to pepsin, there is a profound change in the physical and chemical properties of the protein. In an as yet unknown manner, except that it is i...

1. Carbenoxolone, in suspension at pH 4.0, inhibits swine pepsin A, and human pepsins 1,3 and 5. Human pepsin 5 is the most readily inhibited, and human pepsin 1 the least. 2. Inhibition occurs by a process which is time-dependent, temperature-dependent and proportional to the quantity of carbenoxolone suspended. 3. Carbenoxolone, in solution at pH 7.4 and pH 8.0, inhibits the activation of the...

The aims of the present study was to determine whether or not abomasal damages occurs in calves with abdominal distention using by plasma pepsinogen levels and positivity fecal occult blood test (FOBT). In study, 30 (distention group) 15 clinically healthy (control group), aged between 1-90 days, were used. Collected samples all used levels, bovine specific ELISA. Fresh stool also taken from re...

gastric cancer is the most common gi cancer. it has a very high incidence rate in the northeastern iran.contrary to western countries and japan, the incidence of gastric cancer has been increasing in iran during the past two decades. helicobacter pylori infection is the most important risk factor for developing gastric cancer. however, the presence and influence of other environmental and genet...

background despite the similar rate of hp infection, the rate of gastric cancer (gc) differs in different regions of the country. there are conflicting reports for using a panel of serologic tests such as pepsinogens i, ii (pg i and pg ii), and gastrin for population screening. we designed this study to assess healthy appearing adults in shiraz, southern iran in order to evaluate the correlatio...

background: currently, non-invasive methods for screening atrophic gastritis and gastric cancer are lacking. the purpose of this study was to evaluate the value of serological parameters including serum pepsinogen i (pgi), pepsinogen ii (pgii) and pepsinogen i: ii ratio for the screening atrophic gastritis and gastric cancer.   methods : the study population consisted of 132 dyspeptic patients ...