Perforation is a life-threatening complication of peptic ulcer disease. Smoking and use of non-steroidal anti-inflammatory drugs are important risk factors for perforation. Diagnosis is made clinically and confirmed by the presence of pneumoperitoneum on radiographs. Nonoperative management is successful in patients identified to have a spontaneously sealed perforation proven by water-soluble c...

Peptic ulcer disease is usually diagnosed on the basis of well recognised symptoms confirmed by endoscopy or barium study. Within the community an unknown number of people, however, may have peptic ulcer disease without symptoms, some of whom present only because of haemorrhage or perforation. Roughly a third of the cases of perforated peptic ulcer, for example, occur in people without any prev...

References 1. Ellershaw JE, Kelly MJ. Corticosteroids and peptic ulceration. Palliat Med 1994; 8: 313-319. 2. Conn HO, Blitzer BL. Non-association of adrenocorticosteroid therapy and peptic ulcer. N Engl JMed 1976; 294: 473-479. 3. Piper JM, Ray WA, Daugherty JR, Griffin MR. Corticosteroid use and peptic ulcer disease: role of non-steroidal anti-inflammatory drugs. Ann Intern Med 1991; 114: 735...

Monson, R. R. (Harvard School of Public Health, Boston, Mass. 02115). Familial factors in peptic ulcer. I. The occurrence of ulcer in relatives. Amer. 1. Epid., 1970, 97: 453-459—The occurrence of peptic ulcer in relatives of physicians with a history of ulcer has been compared to that in relatives of physicians without ulcer. About twice as many duodenal ulcers as expected occurred in relative...

Gastrointestinal perforations are a complication of 2-10% of duodenal ulcers. There are a variety of etiologies associated with duodenal ulcer formation and its complications. Corticosteroid use is associated with an increased risk of duodenal ulcer perforation, with the first documented case in 1950. Other important medications associated with perforation include NSAIDS and opioids. Beyond med...

Phytogenic agents have traditionally been used by herbalists and indigenous healers for the prevention and treatment of peptic ulcer. This article reviews the anti-acid/anti-peptic, gastro-protective and/or anti-ulcer properties of the most commonly employed herbal medicines and their identified active constituents. Botanical compounds with anti-ulcer activity include flavonoids (i.e. quercetin...

Liver penetration is a rare but serious complication of peptic ulcer disease. We report a 60-year-old man, without any serious risk factor for peptic ulcer, presented with mild abdominal discomfort, food-related vomiting and weight loss, and a mass in the left hepatic lobe, which was the result of a silent duodenal ulcer penetration. The diagnosis was based on histological examination of the en...

normal 0 false false false en-us x-none ar-sa background: prolonged fasting may precipitate or exacerbate gastrointestinal complaints. the aim of this study was to evaluate the relation between ramadan fasting and acute upper gastrointestinal bleeding (augib), and to assess characteristics of those occurred in the holly month. materials and methods: retrospective analysis was conducted for all ...

BACKGROUND It is presently not well understood to what extent peptic ulcer and gastric cancer represent related diseases. AIMS The objective of this study was to assess past occurrence of gastric and duodenal ulcers in patients with cancer of the gastric cardia or other parts of the stomach. METHODS The association between peptic ulcer and gastric cancer was studied among patients followed ...