background: eukaryotic proteins generally have signal peptides, which are not only crucial for their secretion efficiencies but are important for their expression levels. the coagulation factor ix (fix) is a glycoprotein that plays a fundamental role in a blood coagulation pathway. reduced levels or dysfunctional fix are associated with hemophilia b. to improve the hfix secretion efficiency in ...

Oral administration of food protein hydrolysate and naturally occurring peptides exert beneficial effects beyond conventional nutritional functions by supplying amino acids for synthesis. These are referred to as food-derived bioactive peptides. The coronavirus disease 2019 (COVID-19) is caused sever acute respiratory syndrome 2 (SARS-CoV-2) infection. Some host viral proteins involved in the e...

The OPM (Orientation of Proteins in Membranes) database currently holds, classifies, and annotates around 14,000 three-dimensional structures transmembrane peripheral membrane proteins peptides positioned with respect to boundaries. Developing uniform templates biological membranes realistic native-like lipid composition would provide a convenient accurate platform for researchers who simulate ...

SUMMARY Protein homeostasis (proteostasis) is crucial for proper cellular function, including the production of peptides with biological functions through controlled proteolysis. Proteostasis has roles in maintenance and plant interactions environment under physiological conditions. Plant stress continues to reduce agricultural yields causing substantial economic losses; thus, it critical under...

One of the emerging therapeutic strategies for targeted therapy of cancer is the use of chimeric proteins. The p28 peptide has the ability of selective entrance and activating apoptosis in breast cancer cells. The NRC antimicrobial peptide showed cytotoxic activity on various breast cancer including drug-resistant variants but also normal cell lines. Here we designed a chimeric protein consiste...

One of the emerging therapeutic strategies for targeted therapy of cancer is the use of chimeric proteins. The p28 peptide has the ability of selective entrance and activating apoptosis in breast cancer cells. The NRC antimicrobial peptide showed cytotoxic activity on various breast cancer including drug-resistant variants but also normal cell lines. Here we designed a chimeric protein consiste...

Several antimicrobial peptides suppress the growth of lymph gland (LG) tumors in Drosophila multi sex comb (mxc) mutant larvae. The activity another family polypeptides, called Turandots, is also induced via JAK/STAT pathway after bacterial infection; however, their influence on remains unclear. was activated LG tumors, fat body, and circulating hemocytes mRNA levels Turandot (Tot) genes increa...