a sustained-release tablet formulation should ideally have a proper release profile insensitive to moderate changes in tablet hardness that is usually encountered in manufacturing. in this study, matrix aspirin (acetylsalicylic acid) tablets with ethylcellulose (ec), eudragit rs100 (rs), and eudragit s100 (s) were prepared by direct compression. the release behaviors were then studied in two co...

in the present investigation an attempt has been made to increase therapeutic efficacy, to reduce frequency of administration and to improve patient compliance by developing a sustained release matrix tablets of isosorbide-5-mononitrate. sustained release matrix tablets of isosorbide-5-mononitrate were developed by using different drug: polymer ratios, such in f1 (1:0.75), f2 (1:1), f3 (1:1.5),...

hard gelatin capsule filled with acetaminophen, osmotic agent (sorbitol), a release promoter (sodium dodecyl sulfate), coated with a semipermeable cellulose acetate membrane containing a hydrophobic plasticizer (castor oil) and sealed with white bees wax plug was designed. when placed in the sink water penetrates the membrane, dissolves the osmotic agent and increases the osmotic pressure insid...

This longitudinal prospective study of 22 patients (26 feet) aimed to evaluate the effectiveness of percutaneous surgery in the treatment of hallux rigidus, and to assess patient satisfaction with the result of this surgical approach. Pain levels (VAS), quality of life (SF-12) and clinical stage (AOFAS) were scored prior to surgery and 18 months after surgery. Pain relief was noted in all cases...

T ranscatheter cardiovascular interventions are nowadays more frequently and safely performed, thus leading to populate the heart with medical devices. Here, we describe an unusual complication following percutaneous closure of a patent foramen ovale (PFO) with an atrial septal occluder. A 52-year-old woman with history of transient ischemic attack was found to have a PFO associated with an atr...

We have assessed the release of amethocaine from a new patch delivery system and subsequent drug diffusion through human stratum corneum and whole skin. We found that the patch system was more efficient than an amethocaine gel preparation. It was also observed, both in vitro and in vivo, that the stratum corneum acted as a reservoir for amethocaine. A double-blinded clinical trial, using 30- an...

Objective: To determine the efficacy of trigger finger release with percutaneous technique.
 Study Design: Cross-sectional study.
 Place and Duration Study: Department Orthopedic Surgery, Jinnah Post Graduate Medical Center, Karachi Pakistan, from Mar 2017 to 2018.
 Methodology: One hundred three patients were selected through outpatient department after they meet inclusion crite...

background: the aim of the present study was to develop a scoring system for predicting 1-year major adverse cardiac events (mace), including mortality, target vessel or target lesion revascularization, coronary artery bypass graft surgery, and non-fatal myocardial infarction after percutaneous coronary intervention (pci). methods: the data were extracted from a single center pci registry. the ...

conclusions although by current treatments, the prevalence of patients with low tc, ldl-c and non-hdl-c has significantly increased; dyslipidemia persisted in a considerable proportion of patients. these results necessitate further investigations into the relationship between high serum lipids and long-term outcome of patients after pci as well as further evaluations of the dyslipidemia treatme...