There are many, often life-threatening, rare/orphan diseases for which there are few or no therapeutic options. They individually affect few people, but collectively impose very high social and economic burdens. New approaches are bringing big pharma resources to solving the problem through drug repositioning of approved drugs. Advances are being spurred by public and private partnerships, gove...

Beautiful smile is a booster to person's confidence. Gummy smile is a term used for excessive gingival display (EGD). Its etiology is multifactorial. Bone vertical maxillary excess (VME) is one of the cause of EGD. In this case series, lip repositioning was performed to treat mild to moderate degree of gingival display ( 2 to 8 mm) due to VME. Lip repositioning is simple, promising, meticulous ...

The twiddler syndrome results in retraction and coiling of the lead in the pacemaker pocket with subsequent pacemaker malfunction. If the lead׳s parameters are not affected, then the problem can be corrected by lead repositioning. We describe the first reported case of a dramatic pacemaker lead coiling with a double level of lead compromise, with one of them being intra-cardiac. This condition ...

Correspondence Dr. Isabelle Ayx Radiologie, Barmherzige Brüder Regensburg Prüfeningerstraße 86 93049 Regensburg Germany Tel.: ++ 49/9 41/369943 72 Fax: ++ 49/9 41/3 692523 [email protected] Abstract ▼ Purpose: Evaluation of the technical success rate and complications when retrieving dislocated intravascular foreign bodies. Material and Methods: Between 1999 and 2015 38 patients (21 female; 17 m...

We study mergers among firms that compete by simultaneously choosing price and location. The merged firm moves its two products away from each other to reduce cannibalization, and the nonmerging firms move their products in between the merging firm’s products. Post-merger repositioning increases product variety, which benefits consumers, but repositioning also affects post-merger prices in two ...

Since the first report in 1993, an ectopic centromere, i.e. neocentromere formation, has been reported in more than 100 small supernumerary marker chromosomes (sSMC), in 7 instances of centromere repositioning, and in about a dozen cases with more complex chromosomal rearrangements. Here we report 2 new cases with centromere repositioning and 3 neocentric sSMC consisting exclusively of heteroch...

To determine the characteristics of 12 patients with a diagnosis of benign paroxysmal positional vertigo (BPPV) treated by the repositioning maneuver during a 24-month follow-up period after the initial discharge a longitudinal clinical study was performed in which a questionnaire for the assessment of discomfort caused by dizziness was applied at the first visit, at the last visit after treatm...

Computational drug repositioning methods can scalably nominate approved drugs for new diseases, with reduced risk of unforeseen side effects. The majority of methods eschew individual-level phenotypes despite the promise of biomarker-driven repositioning. In this study, we propose a framework for discovering serendipitous interactions between drugs and routine clinical phenotypes in cross-secti...

BACKGROUND Corneal endothelial damage is a known complication of aqueous shunt surgery. OBJECTIVE To describe a new technique for repositioning the Ahmed glaucoma valve tube in a case of tube-endothelial touch. CASE A patient with advanced glaucoma, having undergone Ahmed glaucoma valve (AVG) implantation, developed localized corneal endothelial damage due to contact between the tube and su...

The cell cycle of the African trypanosome requires a precise orchestration of nuclear and mitochondrial genome (kinetoplast) positioning to ensure faithful segregation during division. The controls underlying these events must be subject to modulation, however, as the respective positioning of these organelles changes during the parasite's complex life cycle. We have studied mitochondrial DNA r...