OBJECTIVE To determine the surgical technique "core out fistulectomy with anal sphincter reconstruction and primary closure of internal opening" in the treatment of trans-sphincteric fistula (high type or long tract) or supra-sphincteric fistula in terms of fistula healing, morbidity, recurrence and anal continence. MATERIAL AND METHOD Between January 2004 and December 2005, 33 patients were ...

Abstract Background Intestinal and perianal fistulas fissures are associated with significant morbidity decreased quality of life in patients Crohn’s disease (CD). We evaluated rates fistula fissure improvements upadacitinib (UPA), an oral selective Janus kinase inhibitor, CD who had or at baseline phase 3 induction maintenance trials. Methods In the U-EXCEL (NCT03345849) U-EXCEED (NCT03345836)...

BACKGROUND Imaging modalities such as endoanal ultrasound or MRI can be useful preoperative adjuncts before the appropriate surgical intervention for perianal fistulas. OBJECTIVES We present a systematic review of published literature comparing endoanal ultrasound with MRI for the assessment of idiopathic and Crohn's perianal fistulas. DESIGN A meta-analysis was performed to obtain pooled v...

AIM The aim of this study was to assess the outcome of fibrin glue in high and low anal fistulas. METHODS A prospective, non-randomized trial was carried out on 30 patients who were diagnosed to have fistulas in ano. They were evaluated by categorizing them into high (with the internal opening above the anorectal ring)(14/30) and low anal fistulas (with the internal opening below the anorecta...

BACKGROUND The aim of this study was to compare the outcomes of the management of perianal fistulas in Crohn disease between infliximab, surgery or a combination of surgery and infliximab. METHODS We prospectively subdivided 35 consecutive patients with Crohn disease with complex perianal fistulas into 3 groups: 11 patients received infliximab (5 mg/kg intravenously at 0, 2 and 6 wk; group A)...

Abstract Objective Perianal fistulizing disease is a problem in patients with Crohn’s (CD) because they often need repetitive surgeries. Among the various available procedures, none of them proves to be superior. In addition, long-term outcome fistula Seton drainage not well described. The aims this study were analyze healing and recurrence rates perianal fistulas CD patients, stratified accord...