Designing positron emission tomography (PET) tracers for targets in the central nervous system (CNS) is challenging. Besides showing high affinity and selectivity their intended target, these have to be able cross blood-brain barrier (BBB). Since only a small fraction of molecules estimated BBB, tools that can predict permeability at an early stage during development are great importance. One s...

development of pore network models for real porous media requires a detailed understanding of physical processes occurring on the microscopic scale and a complete description of porous media morphology. in this study, the microstructure of porous media has been represented by three dimensional networks of interconnected pores and throats which are designed by an object oriented approach. afterw...

the permeability is a main property of oil reservoirs that shows the ability of rocks in the conduct of fluids such as oil, water and gas through the pore spaces of reservoir. the determination of the permeability is a crucial task in reserve estimation, production and development of oil reservoirs. due to this, an accurate estimate of such important reservoir rock parameter should not be made ...

Permeability measurements of engineering textiles exhibit large variability as no standardization method currently exists; numerical permeability prediction is thus an attractive alternative. It has all advantages virtual material characterization, including the possibility to study impact and small-scale parameters. This paper presents results international benchmark, which a first contributio...

The number of new drug candidates that are cleared via noncytochrome P450 (P450) enzymes has increased. However, unlike oxidation by P450, the roles of reductive enzymes are less understood. The metabolism in intestine is especially not well known. The purposes of this study were to investigate the significance of reductive metabolism in human intestine, and to establish a quantitative predicti...

The high interest in the prediction of the intestinal absorption for New Chemical Entities (NCEs) is generated by the increasing rate in the synthesis of compounds by combinatorial chemistry and the extensive cost of the traditional evaluation methods. Quantitative Structure–Permeability Relationships (QSPerR) of the intestinal permeability across the Caco-2 cells monolayer (PCaco-2) could be o...

Characterization of Excavation Damaged Zone (EDZ) around an underground excavation is a major research topic for deep geological disposal of medium to high level radioactive waste. Rock fracturing due to excavation and thermal loading and its resultant rock mass permeability change in the EDZ are important aspects in the EDZ characterisation. A new function to predict rock mass permeability cha...

We investigate the gas flow behavior of unidirectional porous ceramics processed by ice-templating. The pore volume ranged between 54% and 72% and pore size between 2.9 [Formula: see text]m and 19.1 [Formula: see text]m. The maximum permeability ([Formula: see text] [Formula: see text] m[Formula: see text]) was measured in samples with the highest total pore volume (72%) and pore size (19.1 [Fo...

OBJECTIVES Caco-2 monolayers are one of the most widely used in vitro models for prediction of intestinal permeability of therapeutic molecules. However, the conventional Caco-2 monolayer model has several drawbacks including labor-intensive culture process, unphysiological growth conditions, lack of reproducibility and limited throughput. Here, we report on the use of 3-day Caco-2 monolayers f...