While breast milk has been known as a cause of neonatal hyperbilirubinemia, the underlying mechanism of breast milk-induced jaundice has not been clarified. Here, the impact of fatty acids on human UDP-glucuronosyltransferase (UGT) 1A1--the sole enzyme that can metabolize bilirubin--were examined. Oleic acid, linoleic acid, and docosahexaenoic acid (DHA) strongly inhibited UGT1A1 activity. Fort...

CONTEXT Obesity is a multifactorial disorder, that is, a disease determined by the combined effect of genes and environment. In this context, polygenic approaches are needed. OBJECTIVE To investigate the possibility of the existence of a crosstalk between the CALPAIN 10 homologue CALPAIN 5 and nuclear receptors of the peroxisome proliferator-activated receptors family. DESIGN Cross-sectiona...

Peroxisome proliferator-activated receptors (PPARs) are subgroups of nuclear hormonal receptors of transcripting factors mostly found in adipose tissue. They are described as important regulators of lipid and saccharide metabolism including insulin sensitivity; therefore they are taken as marker of metabolic syndrome. Their synthetic ligands could be used as drugs for insulin resistance and typ...

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that regulate gene transcription in response to peroxisome proliferators and fatty acids. PPARs also play an important role in the regulation of adipocyte differentiation. It is unclear, however, what naturally occurring compounds activate each of the PPAR subtypes. To address this issue, a screening assay was est...

Abstract In bovine females, the production of embryos derived from oocytes obtained by ovum pick-up (OPU) is becoming a frequent procedure. Collection pre-pubertal animals enables shortening genetic distance, especially in high-value animals. Nevertheless, oocyte and later embryo developmental potential differ between prepubertal adult heifers. The aim this study was to determine possible under...

Peroxisome proliferator-activated receptors (PPARs) are nuclear and transcriptional modulators with crucial functions in hepatic whole-body energy homeostasis. Besides their well-documented roles lipid glucose metabolism, emerging evidence also implicate PPARs the control of other processes such as inflammatory responses. Recent technological advances, single-cell RNA sequencing, have allowed t...

1Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA 2 Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangl...

1. This proposed Learning Product will review existing evidence of the impacts of community driven development (CDD) on women’s empowerment. It will analyze findings of World Bank Group-supported interventions in countries that have shown commitment to the community driven development approach (that is, have implemented more than one isolated project). It will also draw from the findings of sev...