نتایج جستجو برای: pet32a

تعداد نتایج: 154  

Journal: Iranian Biomedical Journal 2012
Aida Feiz Barazandeh, Ali Jahanian-Najafabadi, Hossein Khanahmad, Mahdi Behdani, Mahdi Habibi Anbouhi, Majid Golkar, Mohammad Ali Shokrgozar, Mohammad Reza Aghasadeghi, Mohsen Abolhassani, Saeid Bouzari,

Background: Targeting of CD20 antigen with monoclonal antibodies has become the mainstay in the treatment of non-Hodgkin's lymphomas and immunotherapeutic depletion of malignant B cells. Accessibility of antigen is one of the crucial factors in development of monoclonal antibodies against this antigen. One major problem in expression of full length CD20 is aggregation and misfolding. Therefore,...

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Journal: :iranian journal of basic medical sciences 0
khadijeh nasiri department of animal science, faculty of agriculture, ferdowsi university of mashhad, mashhad , iran saeed zibaee razi vaccine and serum research institute, agricultural research, education and extension organization (areeo), mashhad, iran mohammadreza nassiri department of animal science and institute of biotechnology, ferdowsi university of mashhad, mashhad, iran mojtaba tahmoorespur department of animal science, faculty of agriculture, ferdowsi university of mashhad, mashhad , iran alireza haghparast department of veterinary medicine, faculty of veterinary medicine, ferdowsi university of mashhad, mashhad, iran

objective(s): enterotoxigenic escherichia coli (etec) strains are one of the primary causes of diarrhea in newborn calves and in humans, pigs, and sheep. igy technology has been identified as a promising alternative to generating a mass amount of specific antibody for use in immunotherapy and immunodiagnostics. the purpose of this study was to produce specific antibody by egg yolk antibody (igy...

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Journal: :iranian journal of virology 0
m frozandeh-moghadam department of medical biotechnology, faculty of medical sciences, tarbiat modares university. tehran, iran r madani department of biotechnology, razi vaccine and serum research institute, karaj, iran mr dehghani department of medical biotechnology, faculty of medical sciences, tarbiat modares university. tehran, iran sl mosavi department of biology, imam hossein university, tehran, iran sa pourbakhsh department of research & diagnosis of poultry disease, razi vaccine and serum research institute, tehran, iran f golchinfar department of biotechnology, razi vaccine and serum research institute, karaj, iran

background and aims: ndv (newcastle disease virus) is one of the viruses that cause disease in avian with severe economic losses in the poultry industry in many countries. fusion protein (f) which plays a major role in the virus pathogenicity contains several regions that have a role in the fusion process. mutation in the sequence of hr1 & hr2 regions of this protein prevents fusion of the viru...

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Journal: :iranian journal of allergy, asthma and immunology 0
hafez heydari-zarnagh department of clinical biochemistry, faculty of medicine, sabzevar university of medical science, sabzevar, iran. kazem hassanpour department of pediatrics, faculty of medicine, sabzevar university of medical science, sabzevar, iran. mohammadjavad rasaee department of biotechnology, faculty of medical science, tarbiat modares university, tehran, iran.

individual preparation of two human t-cell lymphotropic virus type i (htlv-i) diagnostic gst fused peptides (mta-1 and gd21) is time-consuming and expensive. the aim of this study was to design a novel single chimeric antigen (sca) to obviate separate expression of proteins and reduce the cost of reagent preparation.structural protein fragments, including immunodominant b cell linear epitopes, ...

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ژورنال: :پژوهش های آسیب شناسی زیستی 0
haniyeh aghababa department of bacteriology, faculty of medical sciences, tarbiat modares university, tehran, iran ashraf mohabbati mobarez department of bacteriology, faculty of medical sciences, tarbiat modares university, tehran, iran mehrdad behmanesh department of genetics, faculty of biological sciences, tarbiat modares university, tehran, iran nima khoramabadi department of bacteriology, faculty of medical sciences, tarbiat modares university, tehran, iran mehdi nejati head department of bacterial vaccines, production and research complex, pasteur institute of iran, alborz, iran

هدف: کمپلکس آنتی‏ژن 85 مایکوباکتریوم توبرکلوزیس شامل سه پروتئین ترشحی است که خاصیت ایمنی‏زایی دارند. این پروتئین‏ها کاندیداهای مهمی در طراحی واکسن سل هستند. برای استفاده از این پروتئین‏ها به‏عنوان واکسن‏های زیرواحدی یا به‏عنوان یادآور برای bcg نوترکیب یا واکسن‏های dna، تولید آنتی‏ژن‏های پروتئینی به شکل نوترکیب الزامی است. پروتئین‏های مایکوباکتریوم که در دیواره هستند نسبتاً غیرقطبی است و تولید آن...

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ژورنال: :مجله دانشگاه علوم پزشکی اراک 0
لیلا حسن زاده leila hasanzadeh department of biotechnology and microbiology, arak university of medical sciences, arak, iranگروه بیوتکنولوژی و میکروبیولوژی، دانشگاه علوم پزشکی اراک، اراک، ایران حمید ابطحی hamid abtahi department of microbiology, molecular and medical research center, arak university of medical sciences, arak, iranمرکز تحقیقات پزشکی و ملکولی، دانشگاه علوم پزشکی اراک، اراک، ایرانسازمان اصلی تایید شده: دانشگاه علوم پزشکی اراک (arak university of medical sciences) احسان الله غزنوی راد ehsanollah ghaznavi-rad department of microbiology, arak university of medical sciences, arak, iranگروه میکروب شناسی، دانشگاه علوم پزشکی اراک، اراک، ایرانسازمان اصلی تایید شده: دانشگاه علوم پزشکی اراک (arak university of medical sciences) صفیه صوفیان safieh soufian department of biology, payame noor university, arak, iranگروه بیولوژی، دانشگاه پیام نور، اراک، ایرانسازمان اصلی تایید شده: دانشگاه علوم پزشکی اراک (arak university of medical sciences) وحیده فرجادی vahideh farjadi department of microbiology, qom branch, islamic azad university, qom, iranگروه میکروبیولوژی، دانشگاه آزاد اسلامی واحد قم، قم، ایرانسازمان اصلی تایید شده: دانشگاه پیام نور اراک (payame noor university of arak)

زمینه و هدف: هلیکوباکترپیلوری شایع‎ترین باکتری است که جوامع انسانی را در بعد جهانی مبتلا به عفونت ساخته است. ژن vaca از مهم‎ترین شاخص‎های بیماری زایی این باکتری می‎باشد که باعث تشکیل واکوئل‎های اسیدی در سیتوپلاسم سلول و نیز تخریب سلول‎های اپیتلیال می‎شود. هدف از این مطالعه بررسی خواص آنتی ژنیک پروتئین نوترکیب vaca هلیکوباکترپیلوری در سرم انسان و موش آلوده می‎باشد. مواد و روش‎ها: در این مطالعه ت...

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Journal: :iranian journal of microbiology 0
shima mahmoudi pediatric infectious disease research center, tehran university of medical sciences, tehran, iran. setareh mamishi pediatric infectious disease research center, tehran university of medical sciences, tehran, iran and department of infectious disease, children medical center hospital, school of medicine, tehran university of medical sciences, tehran, iran. mona ghazi department of microbiology, school of medicine, shahid beheshti university of medical sciences, tehran, iran. reihaneh hosseinpour sadeghi pediatric infectious disease research center, tehran university of medical sciences, tehran, iran. babak pourakbari pediatric infectious disease research center, tehran university of medical sciences, tehran, iran.

background and objectives: esat-6 (6-kdaearly secretory antigenic target) and cfp-10 (10-kda culture filtrate protein) have been described as dominant antigens recognized by t-cells and considered as virulence factors in mycobacterium tuberculosis . the aim of this study was to clone, express and purify recombinant esat-6 andcfp-10 proteins of m. tuberculosis in soluble form. materials and meth...

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2015
N. Vijay J. Lijo H. J. Dechamma V. Bhanuprakash B. Suresh K. Ganesh G. R. Reddy

BACKGROUND/AIM Recent studies have shown that interleukin-15 (IL-15)is a critical factor for the development and proliferation of CD8(+) memory T cells. The aim of present study is to study the role bovine IL-15 (bIL-15)in activation pathway of bovine CD8(+) T cells if any, which will be useful in designing the adjuvant to increase the duration of immunity of the vaccine preparations. MATERIA...

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ژورنال: :مجله میکروب شناسی پزشکی ایران 0
سمانه صفار samaneh saffar department of clinical biochemistry, school of medicine, tehran university of medical science.گروه بیوشیمی بالینی، دانشکده پزشکی، دانشگاه علوم پزشکی تهران مجید گل کار majid golkar department of parasitology, pasteure institute of iran, tehran, iran مهدی امینیان mahdi amminian department of clinical biochemistry, school of medicine, tehran university of medical science حسام میرشهابی hesam mirshahabi department of virology, school of medicine, tarbiat modares university, tehran, iran. هوشنگ رفعت پناه houshang rafatpanah department of immunology, mashhad university of medical science. تقی گل محمدی taghi golmohammadi department of clinical biochemistry, school of medicine, tehran university of medical science کیهان آزادمنش

زمینه و اهداف:htlv1 اولین رتروویروس انسانی شناخته شده است که در انسان تولید بیماری میکند. عمده فیزیوپاتولوژی بیماری های مربوط به htlv1 به خصوصیات پروتین tax این ویروس مربوط می شود. استفاده از گونه های جهش یافته پروتین tax در کنار دارو های تنظیم کننده سیستم ایمنی می تواند به عنوان تعدیل کننده پاسخ های ایمنی قوی در طراحی واکسن بکار گرفته شود. این پاسخ های ایمنی مضر،باعث بیماری ham-tsp میشود و تعد...

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Journal: :iranian journal of immunology 0
manoochehr rasouli department of immunology, faculty of medical sciences, tarbiat modares university ahmad zavaran hoseini department of immunology, faculty of medical sciences, tarbiat modares university bahram karimi department of parasitology, shahid beheshti university, tehran abdolvahab alborzi division of immunology, prof. alborzi clinical microbiology research center, shiraz university of medical sciences, shiraz, iran simin kiany division of immunology, prof. alborzi clinical microbiology research center, shiraz university of medical sciences, shiraz, iran

background: heat shock protein 70 (hsp70) is present in all organisms studied so far, and is a major immunogen in infections caused by pathogens including leishmania spp. objective: the aim of this study was to clone and express hsp70 from l. infantum strain mcan/ir/96/lon-49 and evaluate antibody response against hsp70 in visceral leishmaniasis (vl). methods: the l. infantum hsp70 gene segment...

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