INTRODUCTION The evaluation of pain intensity is still a subject of research. Mostly psychological evaluations are used. We started to conduct biochemical evaluation in animal experiments. Now we present biochemical evaluation in postoperative pain in man. MATERIAL AND METHODS In 67 patients herniotomy was done. For pre-emptive analgesia morphine and pethidine were used and the following indi...

BACKGROUND AND OBJECTIVE We compared the efficacy of intravenous (IV) paracetamol versus dipyrone via patient-controlled analgesia (PCA) for postoperative pain relief in children. METHODS The study was composed of 120 children who had undergone elective tonsillectomy after receiving general anesthesia. Patients were divided into 3 groups according to the dosage of postoperative intravenous-pa...

INTRODUCTION Shivering is among the unpleasant and potentially harmful side effects of spinal anesthesia. The aim of this randomized double-blind clinical trial was to compare the antishivering effect of two different doses of intrathecal pethidine on the incidence and intensity of shivering and other side effects in patients who underwent cesarean section. METHODS In this study, 150 parturie...

BACKGROUND The usefulness of intravenous patient-controlled analgesia (PCA) with opioids for postoperative analgesia is not well defined. METHODS We systematically searched (MEDLINE, EMBASE, Cochrane Library, bibliographies, any language, to January 2000) for randomised trials comparing opioid-based PCA with the same opioid given intramuscularly, intravenously, or subcutaneously. Weighted mea...

BACKGROUND The study was undertaken to compare the effects of small doses of sufentanil or pethidine on cardiovascular responses induced by tracheal intubation. METHODS Sixty ASA physical status I-II patients, scheduled for elective abdominal surgery under general anesthesia, were randomly allocated in a double blind fashion to receive an intravenous bolus of either sufentanil 0.1 microg/kg (...

Objective: To study the analgesic effect of Caryophyllus aromaticus (flower buds) by formalin test in albino rats. Materials & Methods: Albino rats of either sex were taken and divided into 7 groups with 6 animals in each for central and peripheral analgesic activity by formalin test. 5% formalin is injected into the right dorsal surface of a hind paw of rat after half an hour of drug administr...

Clinicians often hesitate to give adequate doses of narcotic analgesics such as morphine and pethidine because these compounds are known to have a marked respiratory depressant effect. As a result there has been considerable interest in the possibility of combining a dose of one of these analgesics with a small quantity of one of the specific narcotic antagonists. The latter substances are know...