Although the existence of the pancreatic hyperglycemic factor was postulated by Kimball and Murlin (1) in 1923, it was only recently that glucagon was isolated in crystalline form by Staub et al. (2). Glucagon was shown to be a basic polypeptide at that time. Such a peptide would be expected to yield successfully to chromatography on the carboxylic ion exchange resin Amberlite IRC-50, except fo...

An attempt was made to sustain the release of metformin HCl as well as to mask the bitter taste by complexation technique using strong cation-exchange resins, indion 244 and indion 264. The drug loading onto ion-exchange resin was optimized for mixing time, activation, effect of pH, mode of mixing, ratio of drug:resin and temperature. The resinate was evaluated for micromeritic properties, tast...

We synthesized disk-shaped and nano-sized graphene (DSNG) though a novel ion-exchange methodology. This new methodology is achieved by constructing metal ion/ion-exchange resin framework. The morphology and size of the graphene can be modulated by changing the mass ratio of the carbon-containing resin to the cobalt-containing precursor. This is the first time to show that the DSNG formed on the...