A simple and accurate reverse phase liquid chromatographic method was developed for the determination of related substances, degradants and assay of Tolterodine Tartarate active pharmaceutical ingredient used in the treatment of urinary incontinence. A HPLC method was developed for the separation of related substances, degradants obtained from samples generated after stress degradation and also...

BACKGROUND The identification of different (pseudo) polymorphs of an active pharmaceutical ingredient in dry powder formulations is of importance during development and entire product lifecycle, e.g., quality control. Whereas determination of polymorphic differences of pure substances is rather easy, in dry powder formulations, it is generally difficult and the difficulties increase particularl...

Topical analgesics can be defined as topical formulations containing analgesics or co-analgesics. Since 2000, interest in such formulations has been on the rise. There are, however, four critical issues in the research and development phases of topical analgesics: 1) The selection of the active pharmaceutical ingredient. Analgesics and co-analgesics differ greatly in their mechanism of action, ...

There is an ever increasing interest in impurities present in APIs. Now days, not only purity profile but also impurity profile has become mandatory according to various regulatory authorities. In the pharmaceutical world, an impurity is considered as any other inorganic or organic material, or residual solvents other than the drug substances, or ingredients, arise out of synthesis or unwanted ...

In the dispensing process, powdered medicines are often blended with diluents or different kinds of powder. With blending, the mass percent of the medicine in the mixture is unknown until the active pharmaceutical ingredient is determined with techniques such as spectroscopy and chromatography. However, pharmacists need to confirm the exact blending ratio of the dispensing mixture in pharmacies...

variable rate application (vra) based on site specific crop management (sscm) is an effective approach for optimizing the application of agricultural inputs and preventing the undesirable environmental impacts. design, construction and evaluation of a map-based vra system was the main objective followed in this research. for variable rate application based on the generated map, a direct injecti...