Nanosponges are a novel class of hyper-crosslinked polymer based colloidal structures consisting of solid nanoparticles with colloidal sizes and nanosized cavities. These nano-sized colloidal carriers have been recently developed and proposed for drug delivery, since their use can solubilize poorly water-soluble drugs and provide prolonged release as well as improve a drug's bioavailability by ...

Drug toxicity is an important factor that contributes significantly to adverse drug events in current healthcare practice. Application of lipid-based nanocarriers in drug formulation is one approach to improve drug safety. Lipid-based delivery systems include micelles, liposomes, solid lipid nanoparticles, nanoemulsions and nanosuspensions. These carriers are generally composed of physiological...

Nanoemulsions are submicron sized emulsion that is under extensive investigation as drug carriers for improving the delivery of therapeutic agents. These are by far the most advanced nanoparticle systems for the systemic delivery of active pharmaceutical for controlled drug delivery and targeting. These are the thermodynamically stable isotropic system in which two immiscible liquid (water and ...

Polysaccharides and other cationic polymers have been recently used in pharmaceutical research and industry for their properties to control the release of antibiotics, DNA, proteins, peptide drugs or vaccines and have been also extensively studied as non viral DNA carriers for gene delivery and therapy. Among them, chitosan is one of the most used because it promotes long term release of incorp...

The clinical outcome of patients with ischemic heart disease can be significantly improved with the implementation of targeted drug delivery into the ischemic myocardium. In this paper, we present our original findings relevant to the problem of therapeutic heart targeting with use of nanoparticles. Experimental approaches included fabrication of carbon and silica nanoparticles, their character...

Due to their small particle size and large and modifiable surface, nanoparticles have unique advantages compared with other drug carriers. As a research focus in recent years, polyethylene glycol-polylactic acid (PEG-PLA) block copolymer and its end-group derivative nanoparticles can enhance the drug loading of hydrophobic drugs, reduce the burst effect, avoid being engulfed by phagocytes, incr...

Oral delivery is the most accepted and economical route for drug administration and leads to substantial reduction in dosing frequency. However, this route still remains a challenge for the pharmaceutical industry due to poorly soluble and permeable drugs leading to poor oral bioavailability. Incorporating bioactives into nanostructured lipid carriers (NLCs) has helped in boosting their therape...

Effective targeted drug delivery has been a long-held ambition but they are restricted in their utility due to several major drawbacks. The advent of nanotechnology lead to invention of many dosage forms, to circumvent the above limitations, a practical approach has been developed for the formation of discrete functionalized particles, which have been termed as ‘nanosponges’. Nanosponges are ti...

Background: Bioactive compounds need to resist food processing, be released from the matrix, and bioaccessible in gastrointestinal tract order provide health benefits. isolated peach pomace (PP) were encapsulated using four different wall materials improve their stability evaluate effects of vitro digestion, as well chemometric modeling among obtained encapsulates. Methods: Phenolics carotenoid...

Abstract Nutraceuticals have recently gained interest owing to their valuable contribution in the treatment of several diseases, with high safety margin and low incidence side effects. However, efficacy is limited by some challenges, namely poor solubility, permeability, and, consequently, bioavailability. Delivery carriers proven that they can overcome almost all aforementioned limitations, le...