Memantine is a non-competitve NMDA receptor antagonist, but, at variance with the most potent NMDA receptor blockers, such as Ketamine, Phencyclidine and MK-801, has a low affinity for the receptor and its action is voltage/use dependent (Gillin et al., 2009; Johnson & Kotermanski, 2006; Rammes et al., 2008) . Moreover it has been recently demonstrated that this compound selectively blocks the ...

GENERIC NAME PAGE Alfentanil 408 Amobarbital 411 Amphetamine 410 Buprenorphine 408 Butorphanol 408 Caffeine 410 Chlordiazepoxide 411 Cocaine 410 Diazepam 411 Disulfiram 415 Ethanol 412 Fentanyl 408 Flurazepam 411 Heroin 409 Lorazepam 411 LSD 417 GENERIC NAME PAGE Marijuana 416 MDA 418 MDMA 418 Mescaline 417 Methadone 408 Methamphetamine 410 Methylphenidate 410 Midazolam 411 Morphine 409 Nicotin...

A gas chromatography--mass fragmentography--electron impact (GC-MS-EI) assay of phencyclidine (PCP) was adapted for human plasma and urine. This assay is specific for PCP and very sensitive (approximately 1 ng/ml). Patients with the putative diagnosis of PCP overdosage were studied to correlate plasma and urinary levels with clinical state. Urinary PCP levels were enhanced in an acid urine, whi...

A rapid and. precise method for evaluating the miotic activity of cholinergic drugs has been developed based on Long's method, for measuring the rate of mydriasis. The rate of reversal of mydriasis developed, previously in the intact mouse eye by a mild mydriatic (phencyclidine) is used to evaluate the miotic activity. The method provides a useful tool for measuring and comparing the miotic act...

Title: Haloperidol affects bones while clozapine alters metabolic parameters sex specific effects in rats perinatally treated with phencyclidine Authors: Tatjana Nikolic ([email protected]) Milan Petronijevic ([email protected]) Jelena Sopta ([email protected]) Milica Velimirovic ([email protected]) Tihomir Stojkovic ([email protected]) Gordana Jevtic Dozudic...

Estimating the shelf life of reagents and controls is a critical step in evaluating new formulations. We describe several stability assessment techniques, giving particular attention to experimental design. Activation energy was experimentally determined for five major drugs of abuse and metabolites: morphine, 11-nor-delta-9-tetrahydrocannabinol-9-carboxylic acid, amphetamine, phencyclidine, an...

Aliphatic cyclic tertiary amines constitute a major class of naturally occurring and synthetic drugs directed at central biogenic amine receptors. Microsomal metabolism of these amines is known to be associated with low levels of covalent binding and/or suicide inactivation of the pertinent metabolizing P-450 isozymes; two of the more notorious examples are phencyclidine (1-(1phenylcyclohexyl)p...