Polycomb group (PcG) proteins regulate and maintain expression pattern of genes set early during development. Although originally isolated as regulators of homeotic genes, PcG members play a key role in epigenetic mechanisms that maintain the expression state of a large number of genes. All members of the two polycomb repressive complexes (PRC1 and PRC2) are conserved during evolution and while...

PURPOSE Primary congenital glaucoma (PCG) is a severe form of glaucoma that presents early in life. PCG is a clinical and genetic entity that is distinct from juvenile forms of glaucoma. Inheritance is usually autosomal recessive and therefore the disease might be more common in societies where consanguinity is high. We studied the prevalence of cytochrome P450, family 1, subfamily B, polypepti...

The Polycomb group (PcG) gene BMI1 is required for the proliferation and self-renewal of normal and leukemic stem cells. Overexpression of Bmi1 oncogene causes neoplastic transformation of lymphocytes and plays essential role in pathogenesis of myeloid leukemia. Another PcG protein, Ezh2, was implicated in metastatic prostate and breast cancers, suggesting that PcG pathway activation is relevan...

This paper focuses on the denoising of phonocardiogram (PCG) signals by means of discrete wavelet transform (DWT) using different wavelets and noise level estimation methods. The signal obtained by denoising from PCG signal contaminated white noise and the original PCG signal is compared to determine the appropriate parameters for denoising. The comparison is evaluated in terms of signal to noi...

A novel method of detecting mechanical movement of the heart, Mechanocardiography (MCG), with no connection to the subject's body is presented. This measurement is based on radar technology and it has been proven through this research work that the acquired signal is highly correlated to the phonocardiograph signal and acceleration-based ballistocardiograph signal (BCG) recorded directly from t...

Polycomb group (PcG) and trithorax (trxG) proteins are evolutionary conserved factors that contribute to cell fate determination maintenance of cellular identities during development multicellular organisms. The PcG maintains heritable patterns gene silencing while trxG acts as anti-silencing by conserving activation type specific genes. Genetic molecular analysis has revealed extensive details...

This paper is concerned with a synthesis study of the fast Fourier transform (FFT), the short time Fourier transform (STFT and the Wigner distribution (WD) in analysing the phonocardiogram signal (PCG) or heart cardiac sounds.     The FFT (Fast Fourier Transform) can provide a basic understanding of the frequency contents of the heart sounds. The STFT is obtained by calculating the Fourier tran...

With respect to a two-echelon supply chain comprised of retailer and capital-constrained supplier, this paper investigates the effect guarantee on accounts receivable financing with consideration retailer’s default risk three scenarios: no guarantee, third-party offers partial credit (PCG), management company (SCMC) repurchase guarantee. By Stackelberg game model, study finds that: when offer P...

BACKGROUND Proanthocyanidin is a bioflavonoid known to have protective effect against oxidative injury. We investigated the cardioprotective effect of proanthocyanidin. MATERIAL/METHODS Thirty-two Rattus Norvegicus rats were categorized equally as the control group (CG), proanthocyanidin group (PCG), ischemia group (IG) and proanthocyanidin-treated group (PCT). Rats in CG and IG were fed stan...

The Drosophila Polycomb Group (PcG) proteins are required for stable long term transcriptional silencing of the homeotic genes. Among PcG genes, esc is unique in being critically required for establishment of PcG-mediated silencing during early embryogenesis, but not for its subsequent maintenance throughout development. We previously showed that ESC is physically associated in vivo with the Pc...