We investigated whether endoplasmic reticulum (ER) stress was involved in the pathophysiological mechanisms underlying neuronal death of the lateral geniculate nucleus (LGN) after intraocular pressure (IOP) elevation. Five cynomolgus monkeys, four with a glaucomatous left eye after laser photocoagulation treatment and one normal monkey, were studied. At 4, 11, 15 and 24 weeks after the laser ph...

PURPOSE To report the outcomes of transscleral diode laser photocoagulation for treatment of type 1 prethreshold retinopathy of prematurity (ROP). METHODS In this prospective interventional case series, 139 eyes of 73 infants with type 1 prethreshold ROP underwent transscleral diode laser photocoagulation of the avascular retina under topical anesthesia without making a conjunctival incision....

INTRODUCTION Complex retinal arterial macroaneurysms (RAM) are often accompanied by hemorrhage and/or affect the macula. We evaluated the effect of intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy using ranibizumab or aflibercept with or without laser photocoagulation in the treatment of macular edema due to RAM. METHODS A case report of two patients with secondary mac...

Purpose: To compare the histhologic changes in the retina and chowid, between the continuous and pulsed-wave photocoagulation by diode laser in pigmented rabbits. The r6petitivepulse photocoagulation could prove to be a promising technique for several pathologies in the ocular fundus. Methods: Continuous and pulsed diode-laser transpupillary photocoagulation~ was performed in the eyes of pigmen...

This study was designed to evaluate the inhibitory effect of endostatin on choroidal neovascularization (CNV) in laser-induced rat model. Choroidal neovascularization was induced in Brown Norway (BN) rats by diode-laser photocoagulation. Rats were randomly divided into five groups (10 animals in each group): endostatin 20mg/kg group, endostatin 10mg/kg group, laser injury group, normal saline g...

PURPOSE To estimate the 3-year incidence of exudative age-related macular degeneration (AMD) and its treatment by laser photocoagulation in elderly Americans. DESIGN Population-based cohort study using insurance claims data. PARTICIPANTS A random 5% sample of Medicare beneficiaries, age 65 and older. METHODS Incidence of exudative AMD and of laser photocoagulation for this condition was a...