The prevalence of West Nile virus (WNV) infections and associated morbidity has accelerated in recent years. Of particular concern is the recent demonstration that this virus can be transmitted by blood products and can cause severe illness and mortality in transfusion recipients. We have evaluated methylene blue (MB)+light as a safe and cost-effective means to inactivate WNV in vitro. This reg...

The efficacy of chloroaluminum phthalocyanine (AlPc) for photodynamic therapy (PDT) has been evaluated in vitro on acute myeloid leukemia (AML) cells, normal peripheral blood leukocytes (PBL) and mobilized peripheral blood stem cells (mPBSC). The selectivity of the treatment has been evaluated by mixing PBL and TF-1, an erythroleukemic cell line. Upon photoradiation, this photosensitizer leads ...

Porphyrazine macrocycles with bulky peripheral phenylalkylsulfanyl substituents were subjected to photochemical studies. The singlet oxygen generation potential of these was assessed using an indirect method DPBF and all molecules revealed low quantum yields up 0.03. In the photostability study, porphyrazine derivatives underwent photobleaching processes under light irradiation 2.45 ∙ 10−5. pho...

Meta- and para-azidobenzamidine have been prepared and evaluated as photoaffinity labels. The compounds inhibit trypsin reversible in the dark and are competitive with substrate binding. Upon photolysis, irreversible noncompetitive inhibition is observed and is dependent upon concentration, photolysis time, and pH. Specificity of the probes is indicated by experiments in which p-tosyl-l-arginin...

Several studies have suggested that the V0 domain of the vacuolar-type H(+)-adenosine triphosphatase (V-ATPase) is directly implicated in secretory vesicle exocytosis through a role in membrane fusion. We report in this paper that there was a rapid decrease in neurotransmitter release after acute photoinactivation of the V0 a1-I subunit in neuronal pairs. Likewise, inactivation of the V0 a1-I s...

Two novel aggregation-induced emission (AIE) active Schiff bases ( P4C12 and P5C12 ) harnessing excited-state intramolecular proton transfer (ESIPT) process derived from tetraphenylethylene 4-(dodecyloxy)-2-hydroxybenzaldehyde were reported. exhibits photochromism in original powder crystalline states . In contrast, powder, but totally different photochromic fluorescence properties its two poly...