Novel lipid nanoparticulates (NCs) were developed by a combined approach of precipitation and complexation with an aim to improve the solubility, stability and targeting efficiency of glimepiride (GLP). GLP NCs were prepared by precipitation process using PEG 20000 and further complexed with phospholipon90G (P90G). The NCs were evaluated for physicochemical characterization, such as drug lo...

Squalene is a linear triterpene that is extensively utilized as a principal component of parenteral emulsions for drug and vaccine delivery. In this review, the chemical structure and sources of squalene are presented. Moreover, the physicochemical and biological properties of squalene-containing emulsions are evaluated in the context of parenteral formulations. Historical and current parentera...

1031 ISSN 1743-5889 10.2217/NNM.13.95 © 2013 Future Medicine Ltd Nanomedicine (2013) 8(7), 1031–1033 “What is needed in the field is a set of nanoparticle physicochemical characterization and biological evaluation criteria that allow not only the author, but also the reader, to fully understand the mechanism of activity, interpret experimental data and bring standardization that is required for...

This chapter covers the fundamental science, synthesis, characterization, physicochemical properties and applications of oxide nanomaterials. Explains fundamental aspects that determine the growth and behavior of these systems, briefly examines synthetic procedures using bottom-up and top-down fabrication technologies, discusses the sophisticated experimental techniques and state of the art the...

The functional versatility of tetrapyrroles as natural cofactors is related to their conformational flexibility where manipulation of the macrocycle conformation allows a fine-tuning of their physicochemical properties. This feature article gives a personal account of the synthesis and solid state structural characterization of highly substituted, non-planar porphyrins. Their conformational ana...

Characterization and identification of eukaryotic promoter is important for the gene prediction and genome annotation. In this paper, we study the structural characteristics of the core promoters in several eukaryotes through a series of DNA physicochemical properties and adopt a method that combines the alignment and average of multiple promoters and the nonlinear dimensionality reduction tech...

During the course of screening for new antibiotics from rare actinomycetes in our laboratory, a rare actinomycete initially designated as strain A-3416 was found to produce an antibiotic with strong activity against staphylococci resistant to various antibiotics. From its unique physicochemical properties, it was judged to be a new antibiotic and named antibiotic AB-64. In this paper, taxonomic...

Electrospun fibers are promising tissue engineering scaffolds that offer the cells an environment that mimics the native extracellular matrix. Fibers with different characteristics can be produced by the electrospinning technique according to the needs of the tissue to be repaired. In this review, the process of electrospinning was examined, providing a description of the common techniques used...

Extracellular Polysaccharide, Isolation, Characterization Extracellular polysaccharide mixture that forms a viscous mucilate in the fermentation medium during industrial cultivation of Penicillium vermiculatum was isolated by ethanol precipitation and its structural characteristics were investigated by a combination of physicochemical methods. The mixture contained two structurally different po...

Textile effluent is one of the known sources of pollution, which usually contain several chemicals, which contaminate the receiving water. This study was conducted to understand the ability of Bacillus sp., and Pseudomonas sp., on decolourization and normalization of other physicochemical parameters, such as odour, temperature, pH, total solids, total dissolved solids, total suspended solids, t...