Cell-gene therapy is a dynamic constituent of novel medical biotechnology. Neurodegenerative disordersin which damage to or demise of specific brain cell types plays central role, are clear examples of diseasecandidate for cell replacement therapy. Dopaminergic (DAergic) neurons biosynthesize dopamine, a vitalneurotransmitter in the central nervous system. Due to the involveme...

Resting state fMRI may help identify markers of risk for affective disorder. Given the comorbidity of anxiety and depressive disorders and the heterogeneity of these disorders as defined by DSM, an important challenge is to identify alterations in resting state brain connectivity uniquely associated with distinct profiles of negative affect. The current study aimed to address this by identifyin...

The incidence of heat disorders in July and August during 10 yr (1995-2004) reported for the population of Yamanashi prefecture was analyzed, with special consideration of an aging society, in relation to levels and patterns of phases with high daily maximal temperatures. There was an increasing tendency for years with hot summers in comparison to preceding decades. Two climatic characteristics...

Microbes release important metabolites that regulate various physiological activities inside and outside of organisms. The human gastrointestinal tract is a reservoir microbes play regulatory roles in modulating the immune system numerous other functions. Thus, there substantial interest these microbial products their clinical significance. These have shown promise as therapies for cancer, infl...

Neurotrophins including brain-derived neurotrophic factor, BDNF, have critical roles in neuronal differentiation, cell survival, and synaptic function the peripheral central nervous system. It is well known that a variety of intracellular signaling stimulated by TrkB, high-affinity receptor for involved physiological pathological aspects via affecting viability, function, neurogenesis, cognitiv...

One example of work that has a high risk in the world railways is maintenance railway facilities. risks posed comes from noise generated activities carried out. This study used Soundlevel Meter tool to measure intensity facility environment. The measured level equivalent level. also seeks find out impact and what prevention steps have been taken. environment, especially final test, 90.82 dB. ex...

Magnesium, the fourth most abundant cation in human body, is involved several essential physiological, biochemical, and cellular processes regulating cardiovascular function. Mammalian cells regulate Mg2+ concentration through specialized influx efflux transport systems that have only recently been characterized. controlled by cloned transporters including Mrs2p, SLC41A1, ACDP2, MagT1, TRPM6 TR...