An abstract Pick interpolation theorem for a family of positive semi-definite kernels on a set X is formulated. The result complements those in [Ag] and [AM02] and will subsequently be applied to Pick interpolation on distinguished varieties [JKM].

The Sub-millimetre Common User Bolometer Array (SCUBA) at the JCMT employs a chopping and nodding observation technique to remove variations in the atmospheric signal and improve the long term stability of the instrument. In order to understand systematic effects in SCUBA data, we have analysed single–nod time streams from across SCUBA’s lifetime, and present an analysis of a ubiquitous optical...

Niemann-Pick type C (NPC) fibroblasts present a large concentration of cholesterol in their cytoplasm due to a still unidentified deficiency in cholesterol metabolism. The influence of dimethylsulfoxide (DMSO) on the amount of intracellular cholesterol was measured in 8 cultures of normal fibroblasts and in 7 fibroblast cultures from NPC patients. DMSO was added to the fibroblast cultures at th...

This study analyzes impacts by batch picking on picker blocking in narrow-aisle order picking, and determines appropriate batch formations for a better order picking throughput. We present multiple-pick analytical models to offer insights about picker blocking in batch picking. Several simulation studies over a variety of batching situations scrutinize order batching situations which give throu...

This paper presents finite element analysis of the strength of roadheaher conical picks. Failure forms of conical picks are investigated, and the FE model of conical pick is established which is based on ANSYS. The static analysis is carried out according to the load calculated by empirical formula and the deformation map and stress distribution is obtained. The results show that the maximum st...

Warehouse operational costs are heavily influenced by the efficiency in which workers are able to traverse the warehouse and gather items on orders around the warehouse that must be shipped to customers; this action accounts for over 50% of warehouse operations expenses. The act of traversing the warehouse is greatly optimized by following a designated pick path; however, algorithms for pick pa...

A 15-year old girl with slowly progressive gait and speech disorders, and with impairment of mental ability, is decsribed. The disease appeared 18 months before the first hospitalization at the Department of Neurology and Physchiatry for Children and Young People. Neurological and other examinations confirmed extrapyramidal and cerebellar signs, conspisuous knee and ankle reflexes, marked splen...

The neurodegenerative disease Niemann-Pick Type C2 (NPC2) results from mutations in the NPC2 (HE1) gene that cause abnormally high cholesterol accumulation in cells. We find that purified NPC2, a secreted soluble protein, binds cholesterol specifically with a much higher affinity (K(d) = 30-50 nM) than previously reported. Genetic and biochemical studies identified single amino acid changes tha...

performance of the GM-CSF affinity column used to isolate antibodies. If used repeatedly, is it possible that a proportion of high affinity anti–GM-CSF AAs from PAP sera used as a positive control would be retained on the GM-CSF column and released slowly during subsequent purifications of HC IgG? If PAP anti–GMCSF IgG contamination did occur, not only would it account for the immunoblot data g...

Mainstream Information Technology professionals have misunderstood the Pick environment for many years. The Pick environment has been conceived, designed and built with business solutions as its key driver. At its heyday there were over 3,000 business applications available across a very wide range of hardware platforms supporting from 1 to thousands of real time users. The tentative economic r...