I want to dedicate this lecture to the memory of Helen Lester. Helen was wonderful in shaping her words. She will live on in our hearts for what she achieved, just as William Pickles has left a lasting legacy. From his country practice in Wensleydale and his interest in epidemiology he brought the values of primary care to an academic world where secondary care dominated. Half a century later, ...

One factor that is investigated as a possible clue to etiological factors in Autism Spectrum Disorders (ASD) is season of birth. Season of birth effects could be the result of temperature, toxins, dietary changes, viral infections, and cultural or social factors that change seasonally (Bolton, Pickles, Harrington, Macdonald, & Rutter, 1992). A number of studies have looked for season of birth e...

In 1944 a method of Rh blood-grouping, using slanted capillary tubes, was described (Chown, 1944). Further experience with the method led to the appreciation of certain errors in it, which, in 1946, we pointed out, together with ways of preventing them (Chown and Lewis, 1946). Although Discombe and Meyer (1948) reported favourably on the revised method, descriptions of the original one remained...

Although important to heterogeneous catalysis, the ability to accurately model reactions of polyatomic molecules with metal surfaces has not kept pace with developments in gas phase dynamics. Partnering the specific reaction parameter (SRP) approach to density functional theory with ab initio molecular dynamics (AIMD) extends our ability to model reactions with metals with quantitative accuracy...

The addition of various amounts of acetic acid to pureed cucumbers inoculated with Clostridium botulinum spores has shown that outgrowth is inhibited at pH 4.8 but not at pH 5.0. Inoculation experiments with whole cucumbers showed that as little as 0.9% acetic acid in the brine was sufficient to prevent outgrowth from spore inocula as high as 10(6)/cucumber. It was further shown that the rapid ...

Patients with liver disease have been continuously increasing because of excessive consumption of alcohol, inhalation of harmful gases, intake of contaminated food, pickles and drugs. Automatic classification tools may reduce burden on doctors. This paper evaluates the selected classification algorithms for the classification of some liver patient datasets. Classification algorithms considered ...