3-Hydroxyanthranilic acid oxidase is known to cat,alyze the oxidation of 3-hydroxyanthranilic acid to a very unstable aliphatic compound, which may either be spontaneously transformed into quinolinic acid or undergo enzymic conversion to picolinic or nicotinic acid, or both (l-3). According to Mason (4), this enzyme has been classified as an “oxygen transferase,” since the oxygen consumed, 1 mo...

To assess the role of the kynurenine pathway in the pathology of Alzheimer's disease (AD), the expression and localization of key components of the kynurenine pathway including the key regulatory enzyme tryptophan 2,3 dioxygenase (TDO), and the metabolites tryptophan, kynurenine, kynurenic acid, quinolinic acid and picolinic acid were assessed in different brain regions of triple transgenic AD ...

In order to obtain and then test pharmocologically any possible conformers of the new feasible analgesic N-benzyl-4-hydroxy-1-methyl-2,2-dioxo-1H-2λ⁶,1-benzothiazine-3-carboxamide, its 4-O-sodium salt was synthesized using two methods. X-ray diffraction study made possible to determine that, depending on the chosen synthesis conditions, the above-mentioned compound forms either monosolvate with...

Primary leaves of 7- to 9-day-old etiolated seedlings of Phaseolus vulgaris L. var. Red Kidney infiltrated in darkness with aqueous solutions of alpha, alpha'-dipyridyl, o-phenanthroline, pyridine-2-aldoxime, pyridine-2-aldehyde, 8-hydroxyquinoline, or picolinic acid synthesize large amounts of magnesium protoporphyrin monomethyl ester and lesser amounts of magnesium protoporphyrin, protoporphy...

Abstract Background Altered glutamatergic neurotransmission and neuropeptide levels play a central role in migraine pathomechanism. Previously, we confirmed that kynurenic acid, an endogenous antagonist, was able to decrease the expression of pituitary adenylate cyclase-activating polypeptide 1–38, with known migraine-inducing properties. Hence, our aim reveal peripheral kynurenine pathway (KP)...

A computational protocol has been developed to solve the bounded vibrational Schrödinger equation for up to three coupled coordinates on any given effective potential energy surface (PES). The dynamic Wilson G-matrix is evaluated from the discrete PES calculations, allowing the PES to be parametrized in terms of any complete, minimal set of coordinates, whether orthogonal or nonorthogonal. The ...

Oor N-arylated aminophenol products constitute a common structural motif in various potentially useful therapeutic agents and/or drug candidates. We have developed a complementary set of Cuand Pd-based catalyst systems for the selective Oand N-arylation of unprotected aminophenols using aryl halides. Selective O-arylation of 3and 4-aminophenols is achieved with copper-catalyzed methods employin...

Breast cancer (BrCa) is the leading cause of cancer related death in women. While current diagnostic modalities provide opportunities for early medical intervention, significant proportions of breast tumours escape treatment and metastasize. Gaining increasing recognition as a factor in tumour metastasis is the local immuno-surveillance environment. Following identification of the role played b...

Historical and clinical aspects of pellagra and its relationship to alcoholism are reviewed from a biochemical perspective. Pellagra is caused by deficiency of niacin (nicotinic acid) and/or its tryptophan (Trp) precursor and is compounded by B vitamin deficiencies. Existence on maize or sorghum diets and loss of or failure to isolate niacin from them led to pellagra incidence in India, South A...