Pigmentary mosaicisms are nevoid diseases characterized by the presence on the skin of hyperor hypopigmented macules with particular clinical patterns. Occasionally they show association with extracutaneous defects that may alter the normal development of the affected person. We present a compilation of all the cases of pigmentary mosaicism evaluated at our Department in the past decade (Dermat...

Case report A 3-year-old boy was seen at the Department of Maxillo-Facial Surgery and Paediatric Dentistry of the Children’s Hospital of Trieste. The multi-systemic features of XLPDR included a number of oro-dental manifestations such as misshapen teeth, scissor bite, swallowing difficulties, agenesis of the 4 permanent second premolars, taurodontism, early resorption of deciduous roots, and pr...

X-linked reticulate pigmentation disorder with systemic manifestations (XLPDR) is an extremely rare genodermatosis with recessive X-linked inheritance but unknown molecular basis. In males, cutaneous involvement is characterized by reticulate hyperpigmentation of the skin that is associated with a typical facies and severe systemic involvement. In the carrier females, manifestations are apparen...

Knowing the role of MC1R in skin tanning can provide a brand new idea to resolve pigmentary disorders. α MSH has 13 amino acids and is the most essential pigmentary melanocortin responsible for melanin synthesis. One could utilize the compound library to find lead compounds by virtual screening from peptide database and traditional Chinese medicine (TCM) database@Taiwan. Computational simulatio...

This study involved a group of 407 patients (799 eyes) with pigment dispersion syndrome gathered from a glaucoma population of 9200 patients. The sex distribution was equal. The majority (65 Y.) of patients were myopic. The incidence of retinal detachment was 6-4 %. No patients were black, but 5 were mulatto. Approximately one-quarter of the patients with pigment dispersion syndrome (31 % of th...

The acquired pigmentary skin disorder known as vitiligo, which appears white macules and patches all over the body, is brought on by lack of pigment-producing cells from epidermis. Micro needling has been utilized in Vitiligo treatment. Simple injection needles or microneedling tools like manual rollers, derma automated needle pens, micro fractional radiofrequency can be used to perform procedu...

SummaryBackground Most patients with facial pigmentary disorders have multiple disorders. However, there is no definitive treatment algorithm improving various simultaneously. Objectives To investigate the clinical efficacy and safety of combination Q-switched alexandrite carbon dioxide lasers ZO SKIN HEALTHⓇ for Patients/methods This prospective o...

PURPOSE To investigate the relationship between the early signs of age-related macular degeneration (AMD) and the risk of developing exudative AMD (typical AMD or polypoidal choroidal vasculopathy [PCV]) in the fellow eye of Japanese patients with unilateral exudative AMD, focusing particularly on eyes with only pigmentary abnormality. METHODS This study is a retrospective observational conse...

To investigate whether pigmentation genes involved in the melanogenic pathway (melanogenesis) contributed to melanoma predisposition, we compared pigmentary genetics with quantitative skin pigmentation measurements, the number of atypical nevi, the total nevus count, and the familial atypical multiple mole and melanoma (FAMMM) syndrome. We typed 32 pigmentary SNP markers and sequenced MC1R in 2...

OBJECTIVE To test the hypothesis that the retinal pigment epithelial/photoreceptor complex is affected in patients with pigment dispersion syndrome and/or in patients with pigmentary glaucoma. METHODS Electro-oculograms were recorded from patients with pigment dispersion syndrome, pigmentary glaucoma, ocular hypertension, and primary open-angle glaucoma and from control subjects. Electro-ocul...