Overexpression of the CXCR4 receptor is a hallmark of chronic lymphocytic leukemia (CLL) and is important for CLL cell survival, migration, and interaction with their protective microenvironment. In acute myelogenous leukemia (AML), PIM1 was shown to regulate the surface expression of the CXCR4 receptor. Here, we show that PIM (proviral integration site for Moloney murine leukemia virus) kinase...

Theileria parva is a tick-transmitted apicomplexan parasite that infects cattle and African buffalo. In cattle, it causes a fatal lymphoproliferative disease called East Coast fever. The polymorphic immunodominant molecule (PIM) is expressed by two stages of the parasite: the sporozoite, which is inoculated by the tick to infect mammalian lymphocytes, and the schizont, the established intralymp...

The serine/threonine family of Pim kinases function as oncogenes and have been implicated in prostate cancer progression, particularly in hormone-refractory prostate disease, as a result of their antiapoptotic function. In this study, we used a pharmacologic inhibitor targeting the Pim family members, SGI-1776, to determine whether modulation of Pim kinase activity could alter prostate cancer c...

Although conventional therapies for acute myeloid leukemia (AML) and diffuse large B-cell lymphoma (DLBCL) are effective in inducing remission, many patients relapse upon treatment. Hence, there is an urgent need for novel therapies. PIM kinases are often overexpressed in AML and DLBCL and are therefore an attractive therapeutic target. However, in vitro experiments have demonstrated that intri...

Constitutively activating internal tandem duplication (ITD) mutations of the receptor tyrosine kinase FLT3 (Fms-like tyrosine kinase 3) play an important role in leukemogenesis, and their presence is associated with poor prognosis in acute myeloid leukemia (AML). To better understand FLT3 signaling in leukemogenesis, we have examined the changes in gene expression induced by FLT3/ITD or constit...

Provirus integration site for Moloney murine leukemia virus (pim-1) is a proto-oncogene that is linked to the development and progression of several cancers. In this study, we evaluated pim-1 expression in tumors, tumor stroma and tumor-adjacent mucosa together as an independent prognostic factor for colon cancer patients. The study included 343 colon cancer patients. Immunohistochemical staini...

Currently, data-intensive applications are gaining popularity. Together with this trend, processing-in-memory (PIM)–based systems being given more attention and have become relevant. This article describes an analytical modeling tool called Bitlet that can be used in a parameterized fashion to estimate the performance power/energy of PIM-based system and, thereby, assess affinity workloads for ...

In this article, we introduce a methodology aiming to blend modern business applications, which consist of cooperating business components with objectified legacy systems. This methodology is designed in line with the MDA(ADM) philosophy. This legacy application integration methodology encompasses three phases: forward engineering, reverse engineering and linking. The forward engineering phase ...

Information fragmentation is a well-known issue in personal information management (PIM). In order to overcome this problem, various PIM solutions have focussed on linking documents via semantic relationships. More recently, task-centered information management (TIM) has been introduced as an alternative PIM paradigm. While these two paradigms have their strengths and weaknesses, we aim for a n...

A model-driven architecture (MDA) transforms a platformindependent model (PIM) into a platform-specific model (PSM) before it transforms the PSM into code. OOHDM together with a recently proposed business process extension allows to model hypermedia-based and advanced Web applications by an object model which is a platformindependent. But an OOHDM model cannot directly be used as PIM since it i...