In his Kelly West Award Lecture, Narayan suggested that the pathogenesis of type 2 diabetes may be fundamentally different in high-risk populations who vary dramatically in degree of adiposity (1). For example, he raised the possibility that type 2 diabetes was due to “poor insulin secretion” in thin individuals (Asian Indians), whereas the culprit was “poor insulin action” in overweight/obese ...

OBJECTIVE—Linkage to type 2 diabetes has been reported on chromosome 1q21-25 in Pima Indians. Fine mapping identified single nucleotide polymorphisms (SNPs) near the CACNA1E gene associated with this disease. CACNA1E encodes the voltage-dependent calcium channel Cav2.3 Ca 2 , and mice lacking this channel exhibit impaired glucose tolerance and insulin secretion. Therefore, CACNA1E was investiga...

<p>Diabetes mellitus is a chronic disease that affects many people in the world badly. Early diagnosis of this paramount importance as physicians and patients can work towards prevention mitigation future complications. Hence, there necessity to develop system diagnoses type 2 diabetes (T2DM) at an early stage. Recently, large number studies have emerged with prediction models diagnose T2...

We show genetic programming (GP) populations can evolve under the influence of a Pareto multi-objective fitness and program size selection scheme, from “perfect” programs which match the training material to general solutions. The technique is demonstrated with programmatic image compression, two machine learning benchmark problems (Pima Diabetes and Wisconsin Breast Cancer) and an insurance cu...

BACKGROUND Point of Care testing (POCT) provides on-site, rapid, accessible results. With current South African anti-retroviral treatment guidelines, up to 4 fingersticks /patient/clinic visit could be required if utilizing POC. We determined the feasibility and accuracy of a nurse performing multiple POCT on multiple fingersticks followed by simplification of the process by performance of mult...

Genome-wide association studies (GWASs) have been used to search for susceptibility genes for type 2 diabetes and obesity in the Pima Indians, a population with a high prevalence of both diseases. In these studies, a variant (rs2025804) in the LEPR gene was nominally associated with BMI in 1,082 subjects (P = 0.03 adjusted for age, sex, birth year, and family membership). Therefore the LEPR and...

CC-BY-ND 4.0 International license peer-reviewed) is the author/funder. It is made available under a The copyright holder for this preprint (which was not. Abstract Gossypium barbadense L. (Egyptian and Pima) produces single celled fiber trichomes that are the longest and richest in cellulosic contents in the plant kingdom. Developmental dissection of fiber at the transcriptional level is cruci...

OBJECTIVE Diabetic nephropathy (DN) became the leading cause of death in diabetic Pima Indians in the 1970s, but was superseded by ischemic heart disease (IHD) in the 1980s. This study tests the hypothesis that the rise in the IHD death rate between 1965 and 1998 is attributable to access to renal replacement therapy (RRT). RESEARCH DESIGN AND METHODS Underlying causes of death were determine...

Numerous field experiments were conducted at a wide range of sites in Arizona from 1988 through 1999 involving phosphate (P) fertilization of cotton (Gossypium spp.). A total of 21 site-years were used to study the effects of P on both Upland (G. hirsutum L.) and Pima (G. barbadense L.) varieties. The purpose of these experiments was to evaluate University of Arizona (UA) soil fertility guideli...