This article deals with a methodological framework for Product Information Systems (PIS) Engineering. The objective is to propose an approach for developing PIS by reuse of "patterns". These patterns form generic solutions to problems frequently occurring during PIS specification and implementation. Their use would contribute to the rapid development of numerous PIS. A special interest is given...

INTRODUCTION Package insert (PI) is a vital document accompanying a prescribed medication to provide information to the prescriber and end-user at a glance. Studies regarding PIs of Ayurvedic medicines in accordance with standard guidelines are lacking. AIM Present study was undertaken to evaluate PI of Ayurveda drugs. MATERIALS AND METHODS PIs of Ayurveda drugs were obtained from five rand...

OBJECTIVES We examined trends and epidemiology of tuberculosis (TB) across racial/ethnic groups to better understand TB disparities in the United States, with particular focus on American Indians/Alaska Natives (AI/ANs) and Native Hawaiians/other Pacific Islanders (NH/PIs). METHODS We analyzed cases in the U.S. National Tuberculosis Surveillance System and calculated TB case rates among all r...

In this paper we consider the question what is the scientific and career performance of principal investigators (PIs) of publicly funded research projects compared to scientific performance of all researchers. Our study is based on high quality data about (i) research projects awarded in Slovenia in the period 1994–2016 (7508 projects with 2725 PIs in total) and (ii) about scientific productivi...

Cel/Teza: Głównym celem badań jest ocena jakości architektury informacji w witrynach internetowych dwóch partii dominujących obecnie na polskiej scenie politycznej: Prawa i Sprawiedliwości (PiS) oraz Platformy Obywatelskiej (PO).
 Koncepcja/Metody badań: W badaniach wykorzystano triangulację kilku metod badawczych: ocenę jakościowo-heurystyczną stronach WWW PiS PO, ekspercką, analizę porów...

Current treatment strategies for rheumatoid arthritis (RA) consisting of disease-modifying anti-rheumatic drugs or biological agents are not always effective, hence driving the demand for new experimental therapeutics. The antiproliferative capacity of proteasome inhibitors (PIs) has received considerable attention given the success of their first prototypical representative, bortezomib (BTZ), ...

HIV-1 protease inhibitors (PIs) are among the most effective antiretroviral drugs. They are characterized by highly cooperative dose-response curves that are not explained by current pharmacodynamic theory. An unresolved problem affecting the clinical use of PIs is that patients who fail PI-containing regimens often have virus that lacks protease mutations, in apparent violation of fundamental ...

Neuroprotection can be achieved by preventing apoptotic death of postmitotic cells. Apoptotic death can occur by either a caspase-dependent mechanism, involving cytochrome c, apoptosis protease-activating factor-1 (Apaf-1), and caspase-9, or a caspase-independent mechanism, involving apoptosis-inducing factor (AIF). HIV protease inhibitors (PIs) avert apoptosis in part by preventing mitochondri...

OBJECTIVES The aim of this study is to describe the pattern of ill health after personal incapacitant spray (PIS) exposures reported to the National Poisons Information Service-London (NPIS-L) and the Chemical Incident Response Service and to evaluate the relation between sub-categories of PIS exposure and adverse health effects. METHODS Case series study of patients reported to the NPIS-L, b...