نتایج جستجو برای: plant defensin
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Middle ear infection, otitis media (OM), is clinically important due to the high incidence in children and its impact on the development of language and motor coordination. Previously, we have demonstrated that the human middle ear epithelial cells up-regulate β-defensin 2, a model innate immune molecule, in response to nontypeable Haemophilus influenzae (NTHi), the most common OM pathogen, via...
Aim—To determine if â defensins are expressed in the anterior segment of the eye and to determine the temporal pattern of expression using a real time semiquantitative reverse transcription polymerase chain reaction (RT-PCR). Methods—Ocular tissue (corneal epithelium, conjunctiva, iris, and lens capsule) was collected from 23 patients undergoing surgery. Serial corneal or conjunctival impressio...
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The HLA-DR-associated peptides from peripheral blood mononuclear cells of 2 patients with plasmacytoma and 1 with chronic myeloid leukemia were isolated, identified, and compared. Several were identified as derivatives of the defensin family. Defensins (or human neutrophil peptides [HNP]) are antimicrobial, cationic peptides of 29 to 35 amino acids in length and are the major constituents of th...
Submit Manuscript | http://medcraveonline.com Abbreviations: CPITN, communiy periodontal index treatment needs; PSR, periodontal screening & recording; hBD 1, human beta defensin 1; hBD2, human beta defensin 2; LPS, lipopolysaccharides; TNF-α, tumor necrosis factor-alpha; IL-1β, interleukin-1 beta; ELISA, enzyme-linked immunosorbent assay; PBS, phosphate buffered saline; ABTS, 2’-azino-bis-3-et...
BACKGROUND All mucosal epithelia, including those of the tubotympanium, are secreting a variety of antimicrobial innate immune molecules (AIIMs). In our previous study, we showed the bactericidal/bacteriostatic functions of AIIMs against various otitis media pathogens. Among the AIIMs, human beta-defensin 2 is the most potent molecule and is inducible by exposure to inflammatory stimuli such as...
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