BACKGROUND delirium is a frequent neuropsychiatric syndrome affecting medical and surgical elderly patients. Cholinergic dysfunction has been implicated in delirium pathophysiology and plasmatic acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities are suppressed in patients with delirium. In this cohort study, we investigated whether these changes emerge during delirium or w...

A new technique is described for measuring the rate of scoline hydrolysis by plasma cholinesterase, which may prove useful in the diagnosis of scoline sensitivity. The importance of extensive family screening is emphasized and three cases possessing a silent gene are described.

the aim of this trial was to determine the toxic effect of oms-43 on spraymen and inhabitants. the spraying operation lasted for 30 successive days, and two teams consisting of 20 spraymen, 2 mixers, 4 foremen and team leaders were engaged in this operation. the operators were under systematic and closed clinical observation and cholinesterase determination (tintometric method) during the opera...

Toxicity studies of 0,0-diethyl-0-(2- isoprophyl-6-methyl-4-pyrimidinyl) phosphorothioate (DiazinonR) was carried out in the Balami breed sheep. The agent administered orally daily for one week at rate 20, 25 and 30mg/kg body weight to groups dose produced transient clinical signs Diazinon inhibited plasma red blood cell cholinesterase activity. intensity inhibition more with occurred as from d...

organophosphorous compounds have been employed as pesticides and chemical warfare nerve agents. toxicity of organophosphorous compounds is a result of excessive cholinergic stimulation through inhibition of acetyl cholinesterase. clinical manifestations include cholinergic syndromes, central nervous system and cardiovascular disorders. organophosphorous pesticide poisonings are common in develo...

BACKGROUND We aimed to investigate the effects of metoclopramide and ondansetrone on mivacurium neuromuscular blockade. METHODS Seventy five, ASA I-II patients, aged 18-65 and scheduled for elective surgery requiring tracheal intubation were included in the study. The patients received metoclopramide 10 mg, ondansetrone 4 mg or normal saline 5 mL; group M, group O, group NS (n=25), respective...

ôrganophosphorus pesticides have been used in some cases for suicidal attempts. such poison can affect plasma cholinesterase activity. the case was a 47-year-old man hospitalized due to suicide attempt with swallowing agricultural poison. the patient, diagnosed with major depressive disorder (mdd), underwent treatment with electroconvulsive therapy (ëçt). ât the first ëçt session, the patient d...

BACKGROUND Many studies have been conducted in an extensive effort to identify alterations in blood cholinesterase levels as a consequence of disease, including the analysis of acetylcholinesterase (AChE) in plasma. Conventional assays using selective cholinesterase inhibitors have not been particularly successful as excess amounts of butyrylcholinesterase (BuChE) pose a major problem. PRINCI...

BACKGROUND The authors examined the plasma concentrations of the isomers of mivacurium and its pharmacodynamics during spontaeous and neostigmine-facilitated recovery after a mivacurium infusion. METHODS Sixteen patients receiving nitrous oxide-opioid anesthesia received 0.25 mg/kg mivacurium. Patient response to neuromuscular stimulation was determined using a mechanomyograph Once T1 had rec...