sodium valproate and its derivatives have been widely used for anticonvulsant treatment since the 1970s, but in the past decades, due to its pharmacological and biological features, it has been well used in treatment of various psychiatric disorders, such as mood disorders and substance use disorders. sodium valproate is quickly absorbed in about 1-2 hours after oral taking and maximum plasma c...

Polycyclic aromatic hydrocarbons (PAH) are ubiquitous persistent organic pollutants forming as byproducts in combustion processes. These compounds can become nitrated the environment even more toxic nitro derivatives. Both PAHs and nitro-PAHs accumulate soils which lead to pollution of vast areas arable land. The best means their elimination from is bioremediation that degradation by soil micro...

Heparan sulphate and dermatan sulphate have both antithrombotic and anticoagulant properties. These are, however, significantly weaker than those of a comparable amount of standard pig mucosal heparin. Antithrombotic and anticoagulant effects of glycosaminoglycans depend on their ability to catalyse the inhibition of thrombin and/or to inhibit the activation of prothrombin. Since heparan sulpha...

Recent studies have shown that blueberries may have cardiovascular and cognitive health benefits. In this work, we investigated the profile of plasma and urine (poly)phenol metabolites after acute and daily consumption of wild blueberries for 30 days in 18 healthy men. The inter-individual variability in plasma and urinary polyphenol levels was also investigated. Blood samples were collected at...

Curcumin, from the rhizomes of Curcuma longa, is characterized by its anti-diabetic properties, among other healing properties primarily because it is a relatively safe and inexpensive. The application of curcum derivatives for the treatment of experimental diabetes and its complications has paced long ways. Curcumin and its derivatives affect most of aspects of diabetes; including plasma insul...

Plasma levels of alpha 2-plasmin inhibitor (alpha 2PI), plasmin-alpha 2PI complex and cross-linked fibrin derivatives (XDP) were measured in 8 patients (12 episodes) with thromboembolic disorders on the initial administration of urokinase. In conjunction with a decrease in plasma alpha 2PI activity and antigen, plasmin-alpha 2PI complex increased following urokinase infusion in all cases except...

thrombotic thrombocytopenic purpura is the result of multiple thrombus disseminated in small arterioles throughout the body. principle damage is in the endothelium of small vessels and capillaries. from 1982 to 1999, 28 patients (16 female and 12 male) have been treated for ttp. the outcome was evaluated for risk factors and prognosis. these patients were 18 to 69 years old. all had neurologica...

A high-performance liquid chromatographic method that accurately measures glycerol and myo-inositol from plasma and tissue is described. The method incorporates a pre-column derivatization reaction using aqueous extracts with benzoyl chloride as a modifying agent. The benzoylated derivatives are isolated by HPLC using reversed-phase gradient chromatography and quantified via absorbance detectio...

Described is a convenient method for the syntheses of sulfur and selenium containing carbohydrate derivatives of L-gulodeoxynojirimycin and the corresponding C-5 epimer D-mannodeoxynojirimycin. The key step in the synthesis of the latter involves epimerisation of the C-5 hydroxyl group by an oxidation followed by stereo-selective reduction to obtain the desired D-sugar derivative. Both derivati...