a functional treatment for skeletal damages in orthopedic and oral maxillofacial surgeries is required. platelet growth factors such as platelet derived growth factor (pdgf), bone morphogenic factor (bmp), transferring growth factor-β (tgf-β) and insulin-like growth factor-1 (igf-1) proceed wound healing and bone regeneration. in the present study we focused on the effect of platelet rich plasm...

Now a days Platelet-Rich Fibrin (PRF) is gaining more attention for obtaining periodontal regeneration. Platelet-rich fibrin (PRF) is considered a second-generation platelet concentrate that is widely used in osseous regeneration. The purpose of this case report is to present clinical and radiographic results of an intrabony periodontal defect treated with PRF. After surgical treatment with aut...

The effect of autologous platelet rich fibrin (PRF), a second generation platelet product, on the healing of experimental articular cartilage lesions was evaluated in an animal model. Full thickness cartilage lesions with a diameter of 6 mm and depth of 5 mm were created in the weight bearing area of femoral condyles of both hind limbs in 12 adult mixed breed dogs. Defects in the left hind limb...

The aim of this study is to evaluate the use and applicability Platelet-rich Fibrin (PRF) in surgical procedures exodontia. methodology was perform an integrative literature review that developed six phases, which guiding question elaborated by means PICo strategy. Thus bibliographic searches were performed electronic portals PubMed, LILACS Cochrane Library, with keywords Platelet-Rich Fibrin, ...

Platelet concentrates for surgical use are tools of regenerative medicine designed for the local release of platelet growth factors into a surgical or wounded site, in order to stimulate tissue healing or regeneration. Leukocyte content and fibrin architecture are 2 key characteristics of all platelet concentrates and allow to classify these technologies in 4 families, but very little is known ...

Platelet rich fibrin (PRF), developed in France by Choukroun et al(2001), is a second generation platelet concentrate widely used to accelerate soft and hard tissue healing. It’s advantages over the better known platelet rich plasma (PRP) include ease of preparation & application, minimal expense and no need of biochemical blood handling (no bovine thrombin or anticoagulants required). This art...

In the recent years, the unique characteristics of mesenchymal stem cells (MSCs), consisting their angiogenesis and vascularization activity, as well as anti-inflammatory, anti-ulcer and immunosuppressive features plusdifferentiation capability into multilineage cell, have provided huge favorite among clinicians and researchers that theirs experiments has focused on treatment of different disea...