نتایج جستجو برای: platinum azidothymidine
تعداد نتایج: 21795 فیلتر نتایج به سال:
Cis-platinum causes profound gastrointestinal symptoms in patients and these may persist for many days after drug administration. Gut mucosal toxicity may be a factor in the pathogenesis of such prolonged nausea, vomiting and anorexia. The effects of cis-platinum on mouse ileal mucosal architecture, villus epithelial cell influx and disaccharidase activity are described in comparison with dhe e...
Platinum metals have long been used in the glass industry for crucibles and liners because of their high melting points and their chemical inertness to most molten glasses. Contamination of glass by platinum metals has not been reported except in one or two instances where the glasses had a high content of lead or barium. It is well known that heavy lead glasses are more susceptible to colourin...
A range of androgen conjugates with non-conventional platinum(II) complexes have been synthesised with the aim of targeting tumour cells since many display elevated levels of the androgen receptor. The androgenic platinum conjugates are delivered into selected cells with improved efficiency (when compared to their non-steroidal analogues). The act of conjugating an androgen to a platinum(II) co...
Oxaliplatin (cis-[(1R,2R)-1,2-cyclohexanediamine-N,N'] oxalato(2-)-O,O'] platinum; Eloxatine) is a novel platinum coordination complex used for the treatment of metastatic colorectal carcinoma in combination with fluoropyrimidines. The objective of this review is to integrate the key data from multiple studies into a single, comprehensive overview of oxaliplatin disposition in cancer patients. ...
Comproportionation of the platinum(0) complex Pt(PMe3)4 with the platinum(II) hexafluoroacetylacetonate complexes Pt(hfac)2 or [Pt(hfac)(PMe3)2][hfac] yields diplatinum species of stoichiometry [Pt2(μ-hfac)(PMe3)4][hfac], 1, and [Pt2(PMe3)6][hfac]2, 2, respectively. The NMR spectra and X-ray crystal structure of 1 show that the two platinum centers are chemically inequivalent; one is a square-p...
High-Grade Serous Ovarian Carcinoma (HGSOC) is the predominant histotype of epithelial ovarian cancer (EOC), characterized by advanced stage at diagnosis, frequent TP53 mutation, rapid progression, and high responsiveness to platinum-based-chemotherapy. To date, standard first-line-chemotherapy in advanced EOC includes platinum salts and paclitaxel with or without bevacizumab. The major prognos...
The aim was to compare the two most commonly recommended chemotherapy regimens (platinum-based chemotherapy and platinum-taxane combination) with non-platinum-based chemotherapy and those with no chemotherapy in a large nationwide and population-based cohort of patients with ovarian cancer with up to 17 years of follow-up. We studied 12,181 patients diagnosed with stages I-IV ovarian cancer at ...
The synthesis and characterization of two direct platinum (1 and 6a/b) and three ethynyl-platinum corannulene derivatives (2, 8 and 9), bearing 2, 4, or 5 square planar platinum centers, are presented. The structure of the bowl bearing substituents remains comparable to corannulene and the dynamic behavior of the bowl inversion as assessed by VT NMR supports a persistent bowl structure in solut...
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