Severalcis-platinum coordination complexesweretested for their carcinogenic and mutagenic potencies in view of the known electrophilic reactivities of antitumor platinum complexes toward cellular nucleophiles and the mutagen icities of some of these complexes. cis-Dichlorodiammineplatinum(Il) (total dose, 32.5 mg/kg) administered i.p. over 10 to 19 weeks increased the lung adenoma multiplicity ...

Quaternary ammonium palmitoyl glycol chitosan (GCPQ) has already shown beneficial drug delivery properties and been studied as a carrier for anticancer agents. Consequently, we synthesised cytotoxic platinum(IV) conjugates of cisplatin, carboplatin oxaliplatin by coupling via amide bonds to five GCPQ polymers differing in their degree palmitoylation quaternisation. The were characterised 1H 195...

The butyl and isopropyl derivatives (4I, 5Br) of chiral pool derived bis-imidazolium dehydrohexitol salts have been prepared. The ditopic N-heterocyclic carbenes 4 and 5 form dinuclear Ag(I) and Pt(II) complexes. All compounds were fully characterised by multinuclear NMR spectroscopy. The bis-imidazolium salt 4I and platinum complexes cis-[Pt(2)(μ-2)(dmso)(2)Cl(4)] and cis-[Pt(2)(μ-4)(dmso)(2)C...

Some new coordination compounds of tin(IV) having general formula [SnBu2 (L)2 ] (where L = carbohydrazone ligand) have been synthesized by the reaction of dibutyltin oxide with carbohydrazone ligands with the ratio of 1:2 (metal- ligand) using dry benzene as a reaction medium. The newly synthesized complexes were characterized by elemental analysis, molecular weight determinations, conductivity...

The effect of platinum(II) complexes on RNA polymerase II was studied. (D-Glucuronato)(1R,2R-cyclohexanediamine)platinum(II) nitrate (II-GHP) preferentially inhibited RNA synthesis in the presence of S-II, an essential component of eukaryotic transcription. When DNA was pretreated with I-GHP, its template activity decreased significantly, especially when assayed in the presence of S-II. The tar...

A series of platinum(II) complexes bearing Delta (4)-1,2,4-oxadiazoline ligands have been synthesized and characterized. Their in vitro antitumor activity has been assessed in platinum-sensitive and -resistant human ovarian cancer cell lines (PEO1, PEOCisR, PEOCarboR, and SK-OV3), as well as in colon cancer (SW948) and testicular cancer cell lines (N-TERA). All compounds tested showed potent cy...

The synthesis of four novel platinum complexes, bearing N6-(6-amino-hexyl)adenosine or a 1,6-di(adenosin-N6-yl)-hexane respectively, as ligands of mono-functional cisplatin or monochloro(ethylendiamine)platinum(II), is reported. The chemistry exploits the high affinity of the charged platinum centres towards the N7 position of the adenosine base system and a primary amine of an alkyl chain inst...