Glucocorticoid-induced TNFR-related gene (GITR) participates in the immune/inflammatory response. Because GITR expression has been described in cells other than T lymphocytes, we investigated whether it also modulates acute inflammatory response. Using GITR-deficient (GITR(-/-)) mice, we analyzed the role of GITR in the development of carrageenan-induced lung inflammation (pleurisy) by studying...

Background. Inflammation and pain are closely related to humans' and animals' health. Resveratrol (RSV) is a natural compound with various biological activities. The current study is aimed to evaluate the analgesic and anti-inflammatory activities of RSV in vivo. Materials and Methods. The analgesic effects were assessed by the acetic acid-induced writhing and hot plate tests. The anti-inflamma...

Peroxynitrite, a potent cytotoxic oxidant formed by the reaction of nitric oxide (NO) with the superoxide anion, was recently proposed to play a major pathogenic role in the inflammatory process. Here we have investigated the effects of endogenous melatonin, a known scavenger of peroxynitrite, in rats subjected to carrageenan-induced pleurisy. Endogenous melatonin was depleted in rats maintaine...

The intrapleural pressures on the contralateral side in pleurisy with effusion were within the normal range, the normal intrapleural pressures among Indians being ?14 to ?3 cm. of water during inspiration, ?10 to 0 cm. water during expiration, and the mean pressure ?12 to ?2 cm. water (Laha, 1946). Neither the amount nor the duration of effusion had any effect on the intrapleural pressures on t...

A 46-year-old woman developed a right pleural effusion 8 weeks after standard chemotherapy for tuberculous pleurisy on the left side had been started. Pleural biospy demonstrated caseous granulomatous changes. The patient improved following continuation of the same treatment.

The object of treatment in tuberculous pleurisy is to shorten the acute phase of the illness, to restore the integrity of the pleura, and, above all, to prevent further manifestations of tuberculosis. Rest, chemotherapy, and aspiration are each supposed to achieve some of these aims, but their relative importance has not been established. The value of rest was stressed by Roper and Waring (1955...

1 Valdes L. Diagnosis of tuberculous pleurisy using the biologic parameters adenosine deaminase, lysozyme, and interferon gamma. Chest 1993; 103:458-65 2 Ocaiia I, Martinez-Vazquez JM, Segura RM, Fernandez de Sevilla T, Capdevila JA. Adenosine deaminase in pleural fluids: test for diagnosis of tuberculous pleural effusion. Chest 1983; 84:51-3 3 Van Keimpema ARJ. Adenosine deaminase activity, no...

The aim of this work was to analyze the effect of methotrexate (MTX) upon leukocyte migration and expression of adhesion molecules CD11a/CD18 in the lung, 4 and 48 h after inflammation induction by carrageenan in mice. The results showed that MTX significantly decreased leukocyte influx and CD11a expression in the lung at 4 and 48 h of pleurisy (P < 0.01). MTX also inhibited CD18 expression at ...

Endemic pleural plaques are reported from many parts of the world. In Central Europe and in Finland no connection with malignant mesotheliomas has been found, whereas this tumour is often encountered in areas in Turkey where endemic plaques also occur. There seem, however, to be differences in the radiological appearances found in these areas. In the present study chest radiographs of 317 perso...

BACKGROUND Pneumonitis is a rare complication of bacillus Calmette-Guerin (BCG) immunotherapy seen in patients with urothelial cancer following the repeated administration of BCG. However, no case of BCG-induced pleurisy has been reported. CASE PRESENTATION We here report the first case of pneumonitis with lymphocytic pleurisy following bacillus Calmette-Guerin (BCG) immunotherapy. Although m...